U.S. National Library of Medicine

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In September 2004, the Pharmacy and Therapeutics Committee for Nurses, Pharmacists, and Physicians of the Children’s Hospital and Regional Medical Center in Seattle, USA, approved Single Pass Albumin Dialysis (SPAD) for the support of critically ill patients with liver failure: Children's Medication Update: October 2004 [PDF]

SPAD at Children’s Hospital, Seattle

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Wenn ein Organ ausfällt, braucht der Körper Hilfe. Regenerative Medizin könnte eine Selbstheilung ermöglichen, doch einstweilen braucht es Ersatzteile aus Metall, Plastik oder Silizium. Die aktuelle Ausgabe des Journals M.I.T. Technology Review (Deutsche Ausgabe, November 2004) bringt diverse Artikel zum Thema Regenerative Medizin, unter anderem auch bezüglich des Modular Extracorporeal Liver Support (MELS) Konzept.

M.I.T. Technology Review: Regenerative Medizin

The Editor-in-Chief of Artificial Organs informed us that the article "Modular Extracorporeal Liver Support" - published in volume 26, issue 8 of Artificial Organs - was among the top 10 most cited for the year 2003!

Article on "MELS" in top 10 most cited AO articles

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Prior to the GASL meeting 2005 the FALK Symposium No 145: "Artificial Liver Support" will take place in Ulm, January 27-28, 2005.
The Falk Symposium No145 on Artificial Liver Support is held to provide an overview on the possibilities and limitations of the up-to-now existing procedures and devices available for artificial liver support. Future perspectives like stem cell differentiation and their therapeutical implications will also be discussed. Leading experts in the field of artificial devices, bioartificial devices, hepatocyte transplantation and stem cells will present the latest data on the various topics, thus promising a very exciting meeting which will be of high interest for all clinicians involved in the treatment of hepatic failure.
More information via
http://www.medkongresse.de/gasl2005/. The program is available here. Registration may be performed via this document.

FALK Symposium No 145: "Artificial Liver Support"

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For more information on this year's ESAO meeting in Warsaw including the full program please visit http://hrabia.ibib.waw.pl/esao2004/

ESAO 2004: Working Group Liver Support

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More than 200 unique visits were registered during the first month. Thanks for all the comments and critics!

Online Library: Historic Books

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The paper entitled "In vitro comparison of the molecular adsorbent recirculation system (MARS) and single-pass albumin dialysis (SPAD)" (Authors: Igor M. Sauer, Max Goetz, Ingo Steffen, Gesa Walter, Daniel C. Kehr, Ruth Schwartlander, Yoon J. Hwang, Andreas Pascher, Joerg C. Gerlach, Peter Neuhaus) is available (HEPATOLOGY 2004;39:1408-1414)!

The detoxification capacities of single-pass albumin dialysis (SPAD), the molecular adsorbents recirculation system, (MARS) and continuous veno-venous hemodiafiltration (CVVHDF) were compared in vitro. In each experiment 4,100 mL of toxin-loaded human plasma was processed for 6.5 hours. MARS treatment (n = 6) was undertaken in combination with CVVHDF. For SPAD (n = 6) and CVVHDF (n = 6) a high-flux hollow fiber hemodiafilter (identical to the MARS filter) was used. Levels of ammonia, urea, creatinine, bilirubin, and bile acids were determined. Concentrations before and after application of detoxification procedures were expressed as differences and were compared using the Kruskal-Wallis test. Post hoc comparisons for pairs of groups were adjusted according to Bonferroni-Holm. Time, group, and interaction effects were tested using the nonparametric ANOVA model for repeated measurements. SPAD and CVVHDF induced a significantly greater reduction of ammonia levels than MARS. No significant differences were found among SPAD, MARS, and CVVHDF with respect to other water-soluble substances. SPAD induced a significantly greater reduction in bilirubin levels than MARS. Reductions in bile acid levels were similar for SPAD and MARS. When operating MARS in continuous veno-venous hemodialysis mode, as recommended by the manufacturer, no significant differences in the removal of bilirubin, bile acids, urea, and creatinine were found. However, MARS in continuous veno-venous hemodialysis mode was significantly less efficient in removing ammonia than MARS in CVVHDF mode. In conclusion, the detoxification capacity of SPAD is similar to or even greater than that of MARS. (HEPATOLOGY 2004;39:1408-1414.)

Upcoming meetings...

Ruth Schwartlander successfully applied for a grant by the Berliner Graduiertenförderung (NaFöG).

Interest in this webpage...


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INTERNATIONAL SOCIETY OF BLOOD PURIFICATION 2nd Annual Meeting September 3 - 5, 2004 in London From September 3rd through 5th, 2004, the International Society of Blood Purification will hold its 22nd annual meeting at the Royal Free Hospital in London, Great Britain. In keeping with the society's tradition, this meeting will be organized to present cutting edge science in the field of blood purification, dialysis and the management of renal failure.
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XX International Congress of The Transplantation Society September 5 - 10, 2004 in Vienna The XX International Congress of The Transplantation Society will be a celebration of decades of discoveries and application. The Society has promoted an intense cross-fertilization of basic science and clinical medicine and is one of the great examples of how a multidisciplinary approach facilitates progress.
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XXXI Congress of the European Society for Artificial Organs (ESAO) September 8 - 11, 2004 in Warsaw Start of the new century is usually related to introduction of the new ideas and new technological visions. Therefore, theme motto of the XXXI Congress of the ESAO is “Towards Medical Technology of the Future”. We hope that our meeting in Warsaw will result in many presentations of realistic ideas, which will give not only a hope but will lead to efficient substitution or regeneration of the lost functions of the organism.

Ruth Schwartlander receives grant

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In vitro comparison test concerning the MELS CellModule and the AMC-BAL are currently performed in cooperation with the Academisch Medisch Centrum (AMC) in Amsterdam...

Evaluation of bioreactor systems

Via Stüber's Online Library more than 270 historic books in the fields of anatomy, botany, biology and genetics can be accessed. Amongst others Rudolf Virchow's "Die Freiheit der Wissenschaft im modernen Staat" (1877) is available!

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Hepatology: SPAD vs. MARS

Dear Colleagues,
The deadline for abstract submission is approaching (26th of April).
Unfortunately, up to now, very few contributions have been submitted. We ask
all of you to prepare abstracts as well as to stimulate other researchers to
submit appropriate contribution.
Think about supporting ESAO and Warsaw ESAO Congress !

Warsaw ESAO Congress - Abstract submission

Florian Vondran, currently working on his doctoral thesis (cryopreservation of primary human liver cells) qualified for a grant from the Studienstiftung des Deutschen Volkes. As he already receives a grant of the Charité, financial support has been temporarily waived.

Florian Vondran receives grant

The International Program Committee of the 24th International Congress of The
Transplantation Society is pleased to invite the submission of scientific abstracts.

Please use this
link to submit your abstract!