50 ways to love your liver


http://www.oliver-koletzki.de

David Mücke successfully defended thesis

Today, David Mücke successfully defended his thesis magna cum laude with respect to his work on the in vitro evaluation of MRI contrast agents for detection of primary human hepatocytes („In vitro Evaluierung von Magnetresonanztomografie-Kontrastmitteln für die Markierung primärer humaner Hepatozyten“).

Congratulations !

XXXX ESAO Congress in Glasgow

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The European Society for Artificial Organs (ESAO) invites you to the XXXX ESAO Congress of the society to be held in Glasgow (Scotland, UK), September 11th-14th 2013.The motto of the ESAO congress will be 'lab to patient - from concept to treatment.



Latest information is available via www.esao2013.org !

Retreat 2012

Presentations at ESAO 2012 in Rostock, Germany

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This year members of the team gave the following presentations:

“Liver: Current regenerative strategies and future solutions for the liver" (N. Raschzok, oral presentation)

"Neohybrid liver graft - a novel concept of in vivo tissue-engineering" (S. Rohn, oral presentation)

"Micro RNAs in liver regeneration: the mysterious MIR-352" (L. Lisboa, oral presentation)

"Micron-sized iron oxide particles for detection and loco-regional stimulation of transplanted liver cells" (A. Leder, oral presentation)

"Prospective validation of cross organ serum protein biomarkers – Initial results with CXCL9 and CD44 for diagnosis of acute liver rejection" (K.A. Prabowo, poster presentation)

MRI and ectopic liver cell transplantation – new paper

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Nathanael Raschzok’s latest paper on „Feasibility of fast dynamic MRI for noninvasive monitoring during ectopic liver cell transplantation to the spleen in a porcine model“ is now available in AJR Am J Roentgenol. 2012 Jun;198(6):1417-23.
Liver cell transplantation is a promising approach for the treatment of metabolic liver disorders. However, a method for noninvasive monitoring during liver cell transplantation is not available clinically. The aim of this study was to investigate the feasibility of fast dynamic MRI monitoring during liver cell infusion to the spleen, which is considered an ectopic implantation site for liver cell transplantation. Porcine liver cells were labeled with micron-sized iron oxide particles and infused to the spleens of pigs (n = 5) via the lineal artery. MRI was performed using a 3-T MR scanner. Initially, T1- and T2-weighted pulse sequences were tested. Thereafter, fast dynamic MRI was performed during cell infusion. MR findings were verified by immunohistological examinations.

Images from static MRI (TR/TE, 2500/105.2) showed significantly lower signal intensity and signal-to-noise ratio after cell infusion compared with pretransplant images. T2-weighted fast dynamic MRI enabled visualization of signal decrease of the spleen during cell infusion. When cells were infused systemically, no signal changes in the spleen were observed. This study shows that fast dynamic MRI can enable noninvasive monitoring during liver cell transplantation to the spleen. This approach could be useful for preclinical studies and for quality control of clinical liver cell transplantation.

R.B.V. Schmuck received Charité Robert-Koch-Prize 2012

Today, Rosa Schmuck received the 2012 Charité Robert-Koch-Prize for her doctoral thesis entitled „Genotypic and phenotypic characterization of side population of gastric cancer cell lines“ (group of Prof. C. Röcken).

The Side Population (SP) of tumor cell lines shares characteristics with tumor stem cells. In this study we phenotypically and genotypically characterized the SP of gastric cancer cell lines. SPs were obtained from MKN45- and AGS-gastric cancer cells using Hoechst 33342 staining and fluorescence-activated cell sorting (FACS). SP cells were subsequently studied morphologically (cytology, immunocytochemistry), on the transcriptional level (gene array) and in cell culture (recultivation assays). Genes differentially expressed in the SP cells were evaluated by immunohistochemistry in tissue from gastric cancer patients. SP cells were smaller and rounder then Non-SP cells. SP cells self-renewed in re-cultivation experiments and differentiated into SP- and Non-SP cells. Re-cultivated SP- and Non-SP cells showed distinct phenotypes in culture regarding cell shape and colony-formation. SP cells had increased levels of the stem cell markers CD133 and Musashi1. Transcriptional analyses demonstrated that SP cells express genes that encode for stem cell properties like FZD7, HEY1, SMO and ADAM17. Finally she found ADAM17 and FZD7 to be differentially expressed in human gastric cancer, with FZD7- positive intestinal type cancers showing a significant shorter patient survival. In conclusion human gastric cancer cell lines enclose a phenotypically and genotypically distinct cell population with tumor stem cell features. Phenotypical characteristics of this distinct cell population are also present in gastric cancer tissue and seem to correlate with patient survival.

TTS 2012 – Thank you!

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The Science Circuses are located at each end of the Exhibition Area. You will find the Mini-Theatres for the Mini-Oral Sessions here as well as the Poster Lounges and the Web Stations. Science Circus I includes Mini-Theatres 1 – 5; Science Circus II includes Mini-Theatres 6 – 10. In each Science Circus you will find Web Stations where you can access the web as well as the ePosters.
Via wireless headphones and dedicated channels for each mini-theater this is – to our knowledge – the first successful concept for mini-oral presentations!
Thanks to m-events and Interplan for the tremendous support!

TTS 2012 | Over 500 presentations online !

The LOC would like to thank all participants for a tremendous 24th International Congress of The Transplantation Society in Berlin!
2268 abstracts were submitted and more than 4800 delegates from 94 countries attended the congress!
The Postgraduate Weekend offered 14 workshops with 45 speakers. Beside 29 Sunrise Symposia with 103 Speakers, 34 State of the Art Sessions with 138 speakers and five Plenary Sessions (16 speakers) we had 53 sessions with 465 oral presentations and 37 sessions with 287 mini oral presentations !
Furthermore, we would like to thank Astrid Enke, Lena Dochat and Stefanie Rensch (Interplan) and the technical experts at m-Events for their excellent work !
As Science and Medicine is nothing without vivid life we would like to thank Rotfront, Berlin Comedian Harmonists and the Capital Dance Orchestra for their memorable performances!


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All the great photos by Jan Pauls.
The organ sculptures were made by Jan Pareike.

ESAO 2012 – Final Program Online !

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The Transplantation Society is developing a comprehensive educational program for residents, fellows, transplant specialists and related professionals.

The program will now include more than 500 presentations by international experts in all aspects of basic biology and clinical transplantation give during the 24th International Congress of the Transplantation Society
You may access the videos here !

Growing Livers – Jan Pareike's way of doing it...

Prof. Dr. Gustav Steinhoff, congress president of the XXXIX. ESAO Congress, invites you to Rostock on September 26th – 29th, 2012. The venue of the ESAO 2012 congress is the Academy of Music and Theatre, which resides in an old monastery in the city centre.
The motto of the ESAO Congress 2012 will be “from replacement to regeneration – from science to clinic”. The current state of organ assist and organ support allows for a rapidly advancing clinical practice for several hundred thousand patients worldwide.
The scientific program committee did select 59 keynote lectures of renowned international experts, 131 selected oral presentations and 101 poster presentations from worldwide scientific contributors. Nine poster presentations were selected for short oral presentation. We provide a clear program structure by highlighting one special organ system each congress day: heart/cardiovascular (Chair: G. Steinhoff) , liver (Chair: S. Mitzner) and kidney (Chair: W. Ramlow). The program comprises 45 oral and 2 poster sessions with cardiovascular, dialysis, biomaterials and apheresis topics (
www.esao2012.org). Above all the congress program integrates aspects of both basic science and clinical development with a clear focus on translation and clinical practice. We intend to host you on an excellent and exciting congress by inviting outstanding experts and by giving young and promising clinicians and scientists the opportunity to present their work. Especially for young scientists there will be one day for yESAO activities (Tuesday, Sept. 25, 2012). Industry symposia, a poster exhibition and an industrial exhibition will complete the congress program.

We are looking forward to seeing you in Rostock 2012.

TTS 2012 | Presentations

Based on his scientific abstract on “Silica-Based Micron-Sized Iron Oxide Particles for Detection and Loco-Regional Stimulation of Transplanted Liver Cells”, Nathanael Raschzok (and Igor M. Sauer) received the TTS­-DTG International Basic Science Mentee/Mentor Award for the 24th International Congress of The Transplantation Society, in Berlin, Germany. The Basic Science Mentee/Mentor award recognizes the efforts of basic scientists, who have advanced our understanding of transplant science/immunobiology and/or treatment of transplant recipients, as well as the importance of young investigators in furthering the basic science of transplantation.

Congratulations !

TTS­ & DTG Int. Basic Science Mentee/Mentor Award

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The postgraduate program offers an up-to-date overview on pressing clinical and basic science topics with relevance for all participants of the Berlin 2012 meeting. The program is designed to provide clinicians with an overview of the most recent advances in basic research in a bench-to-bedside approach. Updates on immunosuppression, organ-specific processes, organ supply, immune monitoring and the relevance of animal models in transplantation will help both clinicians and researchers with basic information aligning their efforts and providing the best care of transplant patients in the years ahead.

TTS 2012 | Science Circus

Martina Mogl presented "Neohybrid Liver Graft - a Novel Concept of in Vivo Tissue-Engineering"

Rosa Schmuck presented our first results concerning "miRNA Pattern Within the Bile as a Diagnostic Tool after Liver Transplantation"

Nathanael Raschzok gave an oral presentation entitled "Silica-Based Micron-Sized Iron Oxide Particles for Detection and Loco-Regional Stimulation of Transplanted Liver Cells"

Haluk Morgül gave a talk on "MicroRNA as Biomarker for Diagnosis and Prediction of Recurrence of Human Hepatocellular Carcinoma after Liver Transplantation - Preliminary Results from a Multicenter Database"

Furthermore, the group presented a poster concerning "Prospective Validation of Serum Protein Biomarkers for Detection of Acute Liver Rejection – Initial Results with CXCL9 and CD44"

TTS 2012 | Postgraduate Weekend

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Click here to download the TTS App for your iPhone or iPad

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Click here to download the TTS App for your Android Phone

The free TTS Congress App gives users the opportunity to:
• Browse, search and view the Scientific Programme by Speakers, Session, Topics
and Keywords
• Access the Floor Plan to easily find Exhibitors and other meeting locations onsite
• Create your personal schedule

TTS 2012 | Congress App available !


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TTS 2012: Click here to download the On-Site Program as PDF File pdf

TTS 2012 | On-Site Program available !

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Today, Nora N. Kammer and Kristen Steinz successfully defended their thesis!

Nora defended her thesis "summa cum laude". She presented her results on labelling of primary human hepatocytes with micron-sized iron oxide particles in suspension culture suitable for large-scale preparation. In German her thesis is entitled „Markierung primärer humaner Hepatozyten mit mikroskaligen Eisenoxidpartikeln in temporärer Suspensionskultur“.
Kirsten defended her thesis „magna cum laude“. Her work is entitled „Evaluation der Applikationsrouten für die Leberzelltransplantation im Großtiermodell“


Congratulations!

Dr. Nora Kammer & Dr. Kirsten Steinz

ESAO2012

On behalf of the
European Society for Artificial Organs (ESAO), Prof. Dr. med. Gustav Steinhoff invites you to the XXXIX. ESAO Congress to be held in Rostock (Germany), September 26th – 29th, 2012. Rostock is a prospering and easy-to-reach hanseatic city directly located at the Baltic Sea coast. The venue of the ESAO 2012 congress is the Academy of Music and Theatre, which resides in an old monastery in the city centre. Rostock is home to one of the oldest universities in the world: founded in 1419. The motto of the ESAO Congress 2012 will be “from replacement to regeneration – from science to clinic”. The meeting will provide a clear program structure by highlighting one special organ system each congress day: heart/cardiovascular, liver and kidney. Above all the congress program integrates aspects of both basic science and clinical development with a clear focus on translation and clinical practice. We intend to prepare an excellent and exciting congress by inviting outstanding experts and by giving young and promising clinicians and scientists the opportunity to present their work. Especially for young scientists there will be one day for yESAO activities. Industry symposia, a poster exhibition and an industrial exhibition will complete the congress program. More information via www.esao2012.org !

XXXIX. ESAO Congress in Rostock, Germany

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More than 2000 abstract were submitted for the TTS 2012 congress in Berlin. Members of all program committees will meet in Berlin for two days in order to define the Oral, Mini-Oral and Poster sessions.

SlideObserver in Journal of Biotechnology

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The combined meeting of World Apheresis Association (WAA) 11 th Congress and 6 th World Congress of the International Society for Apheresis (ISFA) will take place in Pacifico Yokohama Yokohama, Japan, from March 2―4, 2007. WAA federates many national, continental and international societies for hemapheresis and transfusion science, and ISFA is a representative international society for therapeutic apheresis. They have contributed to the development of these scientific fields for many years.
These two societies serve a regular meeting every two years. This is the first combined congress of the two Societies. It is really an anniversary congress. Many lecture, symposium, workshop and seminars are planned in the congress. Highly scientific papers will be presented at free communications and poster sessions. Several supports will be provided to the participants from developing countries. At the same period, 27 th Annual Meeting of Japanese Society for Apheresis (JSFA) will be held in the adjacent venue. I expect the full communication between foreign guests and Japanese participants.
All scientists, researchers, clinicians and co-medicals of are encouraged to submit abstracts and join this anniversary congress.
More information via
the official webpage.

TTS 2012 - Abstract Meeting in Berlin

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