PD Dr. N. Raschzok & PD Dr. A. Andreou

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Dr. Karl

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Einstein Visiting Fellow Prof. Stefan G. Tullius


Prof. Dr. Stefan G. Tullius, Harvard Medical School, became Einstein BIH Visiting Fellow at the Charité, Department of Surgery.
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Vascular Composite Tissue Allotransplantation (VCA) has developed from a pioneering endevour to a clinical reality during the last 15 years. More than 150 extremity, face, knee, and most recently uterus and penis transplants have been performed during the last 15 years. VCA activities have been seen around the globe. Although feasibility of the procedure has been shown, it is still emerging and far from being a standard clinical procedure.

The Charité has been an international leader in transplantation research for decades. However, neither VCA basic clinical research programs are currently offered in Berlin or Germany in a meaningful way.The involvement of Prof. Tullius as an Einstein BIH Visiting Fellow is expected to synergize and accelerate efforts igniting both a clinical research transplant program and a basic research group of excellence. The overall objective of our integrated basic and clinical research working group Vascular Composite Tissue Transplantation has three main goals:

  1. To establish a basic Research group of Excellence: VCAs offer unique opportunities to study novel aspects of antigenicity, immune modulation and neo-vascularization. One important aspect that distinguishes VCA from solid organ transplants is their blood supply through a vascularized arterial in- and venous outflow in addition to sprouting new vessels at the large interface of VCA with recipient tissue.
  2. To establish a clinical bio-repository as a pre-requisite for a clinical research VCA program.
  3. To implement a clinical VCA research program (hand, abdominal wall, uterus) as a multi- disciplinary and translational effort.

Staatsexamen

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More than 100 days of loops of learning and 3 days conquering more than 300 questions: 5 faces.
Congratulations!
We are all looking forward to having you back in the lab!

Five years BIH Charité Clinician Scientist Program

Dr. Jan Schröder

Today, Jan Schröder successfully defended his thesis (summa cum laude) entitled "Vergleichende in vivo und in vitro Analysen im Rahmen der Etablierung der kombinierten Leber- und Leberzelltransplantation im Rattenmodell" !

Congratulations !

Neujahrsessen 2015 - Sechster Februar, Nudo Berlin

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Rebeka Major: BIH-Promotionsstipendium

Rebeka Major successfully applied for the BIH-Promotionsstipendium grant. Her work will focus in the role of the INDY („I’m Not Dead Yet“) gene in liver regeneration – a project in cooperation with Prof. A. Birkenfeld, Universitätsklinikum Carl Gustav Carus in Dresden.
In the Berlin Institute of Health (BIH), the Max Delbrück Center for Molecular Medicine (MDC) and the Charité - Universitätsmedizin Berlin have joined forces. The core idea is to combine translational research with an overarching systems medicine approach to bridge the gap between basic research and clinical application.

Kristina Kähm – Bachelor of Science

Kristina Kähm successfully completed her bachelor thesis entitled “Analyse von Glykosaminoglykanen und Fibronektinen in der extrazellulären Matrix zum Nachweis der erfolgten Dezellularisierung von Rattenleber-Explantaten“ and is now a Bachelor of science.
Her project was supervised in cooperation with Prof. Dr. Marcus Frohme, Division Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences in Wildau, Germany.

Congratulations !

Dr. med. Carolin M. Langer

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Today, Carolin Langer successfully defended her thesis entitled Evaluierung eines Silizium-basierten Eisenoxidpartikels als intrazelluläres Magnetresonanzkontrastmittel für die Leberzelltransplantation „magna cum laude“.

Cellular therapies require methods for noninvasive visualization of transplanted cells. Micron-sized iron oxide particles (MPIOs) generate a strong contrast in magnetic resonance imaging (MRI) and are therefore ideally suited as an intracellular contrast agent to image cells under clinical conditions. However, MPIOs were previously not applicable for clinical use. her thesis focussed on the development and evaluation of silica-based micron-sized iron oxide particles (sMPIOs) with a functionalizable particle surface. Labeling was stable and had no adverse effects on labeled cells. Silica is a biocompatible material that has been approved for clinical use. sMPIOs could therefore be suitable for future clinical applications in cellular MRI, especially in settings that require strong cellular contrast. Moreover, the particle surface provides the opportunity to create multifunctional particles for targeted delivery and diagnostics.

Congratulations !

Decellularization of rat liver – New time lapse video

Neujahrsessen 2014

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Henriette Riedel successfully defended her thesis

Today, Henriette Riedel successfully defended her thesis entitled Etablierung der kombinierten Transplantation syngener Hepatozyten mit allogenem Lebertransplantat im Rattenmodell zur Untersuchung der Toleranzinduktion „magna cum laude“.

Congratulations !

Retreat 2013

Dr. Nils Billecke

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Today, Nils Billecke successfully defended his doctoral thesis magna cum laude. The title of his presentation was „Bioreaktorsystem zur videomikroskopischen Langzeituntersuchung von Zellen in Mono- und Kokultur“.

Congratulations!

Neujahrsessen

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David Mücke successfully defended thesis

Today, David Mücke successfully defended his thesis magna cum laude with respect to his work on the in vitro evaluation of MRI contrast agents for detection of primary human hepatocytes („In vitro Evaluierung von Magnetresonanztomografie-Kontrastmitteln für die Markierung primärer humaner Hepatozyten“).

Congratulations !

Growing Livers – Jan Pareike's way of doing it...

Prof. Dr. Gustav Steinhoff, congress president of the XXXIX. ESAO Congress, invites you to Rostock on September 26th – 29th, 2012. The venue of the ESAO 2012 congress is the Academy of Music and Theatre, which resides in an old monastery in the city centre.
The motto of the ESAO Congress 2012 will be “from replacement to regeneration – from science to clinic”. The current state of organ assist and organ support allows for a rapidly advancing clinical practice for several hundred thousand patients worldwide.
The scientific program committee did select 59 keynote lectures of renowned international experts, 131 selected oral presentations and 101 poster presentations from worldwide scientific contributors. Nine poster presentations were selected for short oral presentation. We provide a clear program structure by highlighting one special organ system each congress day: heart/cardiovascular (Chair: G. Steinhoff) , liver (Chair: S. Mitzner) and kidney (Chair: W. Ramlow). The program comprises 45 oral and 2 poster sessions with cardiovascular, dialysis, biomaterials and apheresis topics (
www.esao2012.org). Above all the congress program integrates aspects of both basic science and clinical development with a clear focus on translation and clinical practice. We intend to host you on an excellent and exciting congress by inviting outstanding experts and by giving young and promising clinicians and scientists the opportunity to present their work. Especially for young scientists there will be one day for yESAO activities (Tuesday, Sept. 25, 2012). Industry symposia, a poster exhibition and an industrial exhibition will complete the congress program.

We are looking forward to seeing you in Rostock 2012.

Dr. Nora Kammer & Dr. Kirsten Steinz

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On behalf of the
European Society for Artificial Organs (ESAO), Prof. Dr. med. Gustav Steinhoff invites you to the XXXIX. ESAO Congress to be held in Rostock (Germany), September 26th – 29th, 2012. Rostock is a prospering and easy-to-reach hanseatic city directly located at the Baltic Sea coast. The venue of the ESAO 2012 congress is the Academy of Music and Theatre, which resides in an old monastery in the city centre. Rostock is home to one of the oldest universities in the world: founded in 1419. The motto of the ESAO Congress 2012 will be “from replacement to regeneration – from science to clinic”. The meeting will provide a clear program structure by highlighting one special organ system each congress day: heart/cardiovascular, liver and kidney. Above all the congress program integrates aspects of both basic science and clinical development with a clear focus on translation and clinical practice. We intend to prepare an excellent and exciting congress by inviting outstanding experts and by giving young and promising clinicians and scientists the opportunity to present their work. Especially for young scientists there will be one day for yESAO activities. Industry symposia, a poster exhibition and an industrial exhibition will complete the congress program. More information via www.esao2012.org !

Charité's 300-year anniversary in 2010

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The European Journal of Neuroscience published the paper "Mechanisms of hypothermia-induced cell protection mediated by microglial cells in vitro" First author is Antje Diestel from Katharina Schmitt's group - co-authors are Silke Troeller, Nils Billecke, Igor M. Sauer, Felix Berger and Katharina R. L. Schmitt.
Despite the widespread interest in the clinical applications of hypothermia, the cellular mechanisms of hypothermia-induced neuroprotection have not yet been clearly understood. Therefore, the aim of this study was to elucidate the cellular effects of clinically relevant hypothermia and rewarming on the morphological and functional characteristics of microglia. Microglial cells were exposed to a dynamic cooling and rewarming protocol. For stimulation, microglial cells were treated with 1 μg/mL lipopolysaccharide (LPS). We found that hypothermia led to morphological changes from ramified to ameboid cell shapes. At 2 h after hypothermia and rewarming, microglial cells were again ramified with extended branches. Moreover, we found enhanced cell activation after rewarming, accompanied by increased phagocytosis and adenosine triphosphate consumption. Interestingly, hypothermia and rewarming led to a time-dependent significant up-regulation of the anti-inflammatory cytokines interleukin-10 and interleukin-1 receptor antagonist in stimulated microglial cells. This is in line with the reduced proliferation and time-dependent down-regulation of the pro-inflammatory cytokines tumor necrosis factor-alpha and monocyte chemotactic protein-1 in comparison to normothermic control cells after LPS stimulation. Furthermore, degradation of the inhibitor of the nuclear transcription factor-kappaB (IkappaB-alpha) was diminished and delayed under conditions of cooling and rewarming in LPS-stimulated microglial cells. Thus, our results show that hypothermia and rewarming activate microglial cells, increase phagocytosis and shift the balance of cytokine release in stimulated microglial cells towards the anti-inflammatory cytokines. This could be a new cellular mechanism of hypothermia-induced neuroprotection mediated by activated microglial cells.
European Journal of Neuroscience, 2010; 31: 779-787

Haluk Morgül defended thesis "magna cum laude"

N. Raschzok and D. Mücke gave presentations on "Monitoring of liver cell transplantation by MRI" (oral presentation) and " In vitro comparison of iron oxide contrast agents for labelling of human hepatocytes" (poster presentation) at this year's 26th Meeting of the German Association for the Study of the Liver (GASL) in Bonn.

Sarah Illenberger: knit wool organs

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The World Conference on Regenerative Medicine (WRM) will be held from October 29th to October 31st, 2009 in Leipzig. The Fraunhofer Institute for Cell Therapy and Immunology is once again organizer and host of this scientific event and the Translational Center for Regenerative Medicine (TRM) Leipzig has become co-organiser of the event. Main topics will be stem cells, tissue engineering, technology development, immunology, signaling, and regulatory affairs. 
The final program is now available - more information viwww.wcrm-leipzig.com .
Nathanael Raschzok will present our latest results concerning "Tracking of Transplanted Liver Cells in a Preclinical Large Animal Model", Thursday, October 29th, 2009, 04:00-05:30 pm, session: Imaging of Regeneration II, Hall 4.

BMBF Forschungsprämie

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The traditional One Day on the Liver will be part of the XXXVI Annual Meeting of the European Society for Artificial Organs ESAO 2009 at the Université de Technologie de Compiègne in France. ODOL 2009 will take place September, 3rd focussing on "Cells, Hybrids, and Machines".
The following keynote lectures will be given:
Clinical Results of Liver Cell Therapy in Children with Urea Cycle Defect by Dr. Dr. W. Rüdinger, Weinheim, Germany,
Xenotransplantation. Where are we in 2009 ?
by Dr. A. Billiau, Leuven, Belgium,
Problems and Opportunities: Perspectives of Bioartificial Liver Support
by Dr. R. Hoekstra, Amsterdam, Netherlands,
New perspectives of artificial liver support
by Prof. Dr. D. Falkenhagen, Krems, Austria.

We expect to present you all lectures as video streams after the meeting.

Nathanael Raschzok defended thesis "summa cum laude"

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Sehr geehrte Kolleginnen und Kollegen,

die Transplantationsmedizin in Deutschland ist in der Zukunft mit einer Vielzahl von Problemen konfrontiert. Basierend auf hervorragenden Ergebnissen wurden in den letzten Jahren die Indikation zur Transplantation zunehmend großzügiger gestellt. Gleichzeitig führt der andauernde Mangel an Organspendern zu einer steigenden Akzeptanz sogenannter marginaler Organe. Neben diesem zentralen Problem sind sicherlich die steigende Zahl von Patienten zur Retransplantation, Langzeitnebenwirkungen der Immunsuppression sowie die Inzidenz von Malignomen dringende Diskussionpunkte.
Daher lade ich Sie recht herzlich zur 18. Jahrestagung der Deutschen Transplantationsgesellschaft unter dem Motto:’Transplantationsmedizin – Neue Herausforderungen bei gesicherter Routine“ nach Berlin ein.
Neben dem wissenschaftlichen Diskurs möchten wir Sie zu einer Diskussion der aktuellen Probleme und Entwicklungen in der Transplantationsmedizin einladen.
Traditionellerweise wird im Rahmen der Tagung das 13. AKTX-Pflegesymposium am Donnerstag und Freitag stattfinden.
Ich freue mich Sie in Berlin begrüßen zu dürfen, einer Stadt die aufgrund ihrer kulturellen, geschichtlichen und internationalen Präsenz zu einem offenen und zukunftsweisenden Gedankenaustausch einlädt. Neben dem wissenschaftlichen Programm hoffen wir Ihnen auch im Rahmen der Abendveranstaltung etwas von der Attraktivität der Stadt vermitteln zu können.


Ihr Prof. Peter Neuhaus

Thank you for coming and bringing such good cheer !

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On behalf of the European Society for Artificial Organs (ESAO), it is our great pleasure and honour to welcome you to the XXXVI ESAO Congress, which will take place at the University of Technology (UTC) in Compiègne, France.
The University of Technology of Compiègne (UTC) has a special position among the French Universities. Founded in 1973, one of its duties was to link student training, research and industry. More specifically, UTC pioneered the field of biomedical engineering in France, hosting specialists in solid and fluid biomechanics, biomaterials, artificial organs, physiology, medical signals and images, and further areas. The occasion of the present Congress will allow a unique analysis of the “Past and future roles of artificial organs in engineering for health". We will take advantage of the Jubilé for Prof. M.Y. Jaffrin to review the premises and accomplishments of hemodialysis. We will consider the state of the art of research for the most popular artificial organs (kidney, heart, liver), and the promises of new technologies such as regenerative medicine, micro and nanotechnologies, multiscale and integrated approaches. Our aim is to bring together and to foster exchange and collaboration among scientists, clinicians and industrial partners. Located very close to Paris (70 km away), to international Roissy/Charles de Gaulle and Paris-Beauvais airports (both 40 minutes away), Compiègne is very easy to reach. In the valley of the river "Oise", it is a tourist and resort centre with castles, museums and the Armistice Clearing. The castle was the autumn residence of Emperor Napoleon III. Even before today’s castle was constructed, Compiègne was the preferred summer residence for the monarchs of France, primarily for hunting given its proximity to the nearby forest. We look forward to welcoming you in Compiègne for the 2009 edition of the ESAO annual meeting.

Cécile Legallais
Congress President

Dr. med. Dominik Paul Modest

RFMIARRP from Rot Signalgrau on Vimeo.

Inaugurative lecture of Dr. I.M. Sauer

After years of research in the field of hepatocyte isolation and hypothermic long-term culture Dominik Paul Modest successfully defended his thesis "magna cum laude".

Dr. M. Bahra & Dr. I.M. Sauer will celebrate their Habilitation February 6th, 2009

February 5th, 2009 at 4 p.m. (Hörsaal 3, Lehrgebäude Charité - Campus Virchow Klinikum) Dr. I.M. Sauer will give his inaugurative lecture entitled "Künstliche Organe: Von der Vision kybernetischer Organismen zur medizinischen Realität".

Dr. Igor M. Sauer: obtained postdoctoral lecture qualification (Habilitation) in Surgery


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Doors of the Roadrunner's Paradise will open at 9 p.m. - Emigrantski Raggamuffin by Rotfront ahead!

PhD Student Award in Regenerative Medicine

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Acute kidney failure is an important clinical area in the intensive care unit setting. An estimated 5–20% of critically ill patients experience an episode of acute kidney failure during the course of their illness, and about 5% of patients admitted to an ICU will eventually require renal replacement therapy. In these patients, in-hospital mortality is extremely high, exceeding 50%. Thus, the early detection and causal treatment of acute kidney problems is vitally important for a successful outcome. Written by internationally renowned experts, this clinical reference offers helpful advice with the most recent information on definition, epidemiology, pathophysiology, clinical causes of acute kidney failure, differential diagnostic approaches for patients with acute renal failure, and various key aspects related to the adequate delivery of acute renal replacement therapy.
It also gives a detailed outline of important measures for their clinical management. This reference is intended as a helpful guide for all clinicians involved in the care of patients at risk of developing acute kidney problems.

The book is written for all clinicians who are involved in the care of patients at risk of developing acute kidney problems; e.g. fellows and residents in nephrology, intensive care, internal medicine, anaesthesiology, surgery, paediatrics, diagnostic and interventional radiology, urology, cardiology and clinical immunology.

Associated Investigator of BCRT

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The Berlin-Brandenburg School for Regenerative Therapies (BSRT) offers young talented scientists in Berlin and Brandenburg:
Best Publication Award: The award will be granted for the most outstanding paper for progress in Regenerative Medicine accepted by a peer review journal in the last two years. The award comprises 1.500 Euro.
Best Presentation Award: The award will be granted for the best poster presented at an international conference with a peer review system within the last two years. The award comprises 500 Euro.
Info & Contact: BSRT, Charité Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, E-Mail: award@bsrt.de, Web: www.bsrt.de

Dr. med. Florian W.R. Vondran

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As all the recent years the “One day on the liver” – a day dedicated to liver support systems and therapeutic strategies in the case of a failing liver - will take place during the ESAO 2008 meeting in Geneva. For the first time we organised the "Young investigators' Liver Session". We asked the heads of several groups working in the field to send one of their best students to present their latest results. This session is dedicated to PhD students and is chaired by PhD students involved in liver support research. Of course all participants of the meeting are invited to attend!
The ESAO One Day on the Liver 2008 (ODOL) will take place Thursday, Sept. 4th, 2008.

Paul P.C. Poyck (AMC) defended his thesis

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ESAO Board of Governors - I.M. Sauer elected

Paul P.C. Poyck from the Department of Surgery (Experimental Surgery) of the Academic Medical Center (AMC), University of Amsterdam, The Netherlands, successfully defended his thesis entitled "Towards application of a human liver cell line for use in the AMC bioartificial liver".
The Berlin group congratulates him and Prof. Chamuleau for his great work! 

Article among top 10 most cited in AO

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Retreat 2007

The Editor-in-Chief Paul S. Malchesky informed us that the article  "Modular Extracorporeal Liver Support"  is  among top 10 most cited in Artificial Organs for the year 2006.
The article
"`Blogs` and `Wikis Are Valuable Software Tools for Communication Within Research Groups" was number three of the five most-accessed articles in different areas of artificial organs research from 2006.

Charité Biomedical Entrepreneurship Summit

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Paul Poyck published the results of our in vitro comparison of the two bioartificial liver support systems: MELS CellModule and AMC-BAL (Int J Artif Organs. 2007; 30(3):183-191): Clinically applied bioartificial liver (BAL) support systems are difficult to compare with regard to overall hepatocyte-specific function and clinical outcome. We compared two clinically applied BAL systems, the Modular Extracorporeal Liver Support (MELS) CellModule and the AMC-bioartificial liver (AMC-BAL) in an in vitro set-up. Both BAL systems were loaded with 10 billion freshly isolated porcine hepatocytes, cultured for 7 days and tested on days 1, 2, 4 and 7. Average decrease in hepatocyte-specific functions over 7 days was 9.7%. Three parameters differed between both bioreactors: lidocaine elimination at days 1 and 2 was significantly higher in the AMCBAL, ammonia elimination showed a significantly higher trend for the AMC-BAL over 7 days and LDH release was significantly lower at day 7 for the MELS CellModule. In conclusion, this first in vitro comparison of two clinically applied BAL systems shows comparable functional capacity over a period of 7 days.

Dr. rer. medic. Gesine Pless

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Ruth Schwartlaender successfully defended her thesis "summa cum laude". After three years of extremely fruitful research and development she is (co-)author of 8 papers in peer reviewed journals (with more to come...) and gave numerous lectures at international meetings in the field of artificial organs and regenerative medicine. Her work was supported by research grants from the Berliner Graduiertenfoerderung (NaFOG) and the German Federal Ministry of Education and Research (BMBF - 0312111). Her latest results were published in the January issue of Tissue Engineering.

Dr. rer. medic. Ruth Schwartlaender

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Tissue Engineering published the article "Continuously Microscopically Observed and Process-Controlled Cell Culture Within the SlideReactor: Proof of a New Concept for Cell Characterization"  by R. Schwartlander, J. Schmid J, B. Brandenburg, E. Katenz, F.W. Vondran, G. Pless, X. Cheng X, A. Pascher A, P. Neuhaus P, and I.M. Sauer in the January 2007 issue.
Moreover, the editors have chosen one of the figures showing fluorsecent staining of primary human hepatocytes cultured within the SlideReactor as cover-art!
Certain cell types, especially primary human cells, favor a well-defined culture environment offering continuous supply of nutrients and oxygen and waste product removal. Several bioreactors based on special matrices or hollow fibers have been developed that provide such conditions. However, characterization of matrix re-organization or growth of tissue within these systems is possible only after culture termination. Evaluation of the influence of certain medium additives or culture conditions (e.g., temperature, oxygenation) on cell viability, expansion, and differentiation within these systems remains a challenging task. The SlideReactor, a miniaturized hollow fiber-based bioreactor, was developed to enable the observation of cells during culture. An operation concept offering predefined conditions for various cell types has been designed. For proof of concept, primary human cells (hepatocytes, fibroblasts, keratinocytes) and cell lines (HepG2, HuH7, C3A, WiDr, SkHep1) were cultured and observed. A series of experiments (n = 40) showed the feasibility of the set-up; determination of process parameters and continuous observation is possible. The SlideReactor may serve as a simple and cost-efficient tool for cell characterization and optimization of cell-culture conditions.

Charité Welcome Center

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The 43rd Meeting of the Society for Cryobiology in association with the Society for Low Temperature Biology in Hamburg, Germany, July 24-27, 2006, will cover a wide range of subjects including hypothermia, physiology of resistance to cold in plants, and applications of cryobiology in conservation/freeze-drying, surgery, cell, tissue and organ preservation. Relevant aspects of biology, molecular biology, physics, chemistry, physical chemistry, biochemistry, physiology, medicine, transfusion medicine, cryosurgery, cryomicroscopy, mechanical engineering, tissue engineering and transplantation will also be covered.
More information via www.cryo2006.org.

U.S. National Library of Medicine

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In September 2004, the Pharmacy and Therapeutics Committee for Nurses, Pharmacists, and Physicians of the Children’s Hospital and Regional Medical Center in Seattle, USA, approved Single Pass Albumin Dialysis (SPAD) for the support of critically ill patients with liver failure: Children's Medication Update: October 2004 [PDF]

Online Library: Historic Books

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The paper entitled "In vitro comparison of the molecular adsorbent recirculation system (MARS) and single-pass albumin dialysis (SPAD)" (Authors: Igor M. Sauer, Max Goetz, Ingo Steffen, Gesa Walter, Daniel C. Kehr, Ruth Schwartlander, Yoon J. Hwang, Andreas Pascher, Joerg C. Gerlach, Peter Neuhaus) is available (HEPATOLOGY 2004;39:1408-1414)!

The detoxification capacities of single-pass albumin dialysis (SPAD), the molecular adsorbents recirculation system, (MARS) and continuous veno-venous hemodiafiltration (CVVHDF) were compared in vitro. In each experiment 4,100 mL of toxin-loaded human plasma was processed for 6.5 hours. MARS treatment (n = 6) was undertaken in combination with CVVHDF. For SPAD (n = 6) and CVVHDF (n = 6) a high-flux hollow fiber hemodiafilter (identical to the MARS filter) was used. Levels of ammonia, urea, creatinine, bilirubin, and bile acids were determined. Concentrations before and after application of detoxification procedures were expressed as differences and were compared using the Kruskal-Wallis test. Post hoc comparisons for pairs of groups were adjusted according to Bonferroni-Holm. Time, group, and interaction effects were tested using the nonparametric ANOVA model for repeated measurements. SPAD and CVVHDF induced a significantly greater reduction of ammonia levels than MARS. No significant differences were found among SPAD, MARS, and CVVHDF with respect to other water-soluble substances. SPAD induced a significantly greater reduction in bilirubin levels than MARS. Reductions in bile acid levels were similar for SPAD and MARS. When operating MARS in continuous veno-venous hemodialysis mode, as recommended by the manufacturer, no significant differences in the removal of bilirubin, bile acids, urea, and creatinine were found. However, MARS in continuous veno-venous hemodialysis mode was significantly less efficient in removing ammonia than MARS in CVVHDF mode. In conclusion, the detoxification capacity of SPAD is similar to or even greater than that of MARS. (HEPATOLOGY 2004;39:1408-1414.)

Interest in this webpage...


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INTERNATIONAL SOCIETY OF BLOOD PURIFICATION 2nd Annual Meeting September 3 - 5, 2004 in London From September 3rd through 5th, 2004, the International Society of Blood Purification will hold its 22nd annual meeting at the Royal Free Hospital in London, Great Britain. In keeping with the society's tradition, this meeting will be organized to present cutting edge science in the field of blood purification, dialysis and the management of renal failure.
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XX International Congress of The Transplantation Society September 5 - 10, 2004 in Vienna The XX International Congress of The Transplantation Society will be a celebration of decades of discoveries and application. The Society has promoted an intense cross-fertilization of basic science and clinical medicine and is one of the great examples of how a multidisciplinary approach facilitates progress.
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XXXI Congress of the European Society for Artificial Organs (ESAO) September 8 - 11, 2004 in Warsaw Start of the new century is usually related to introduction of the new ideas and new technological visions. Therefore, theme motto of the XXXI Congress of the ESAO is “Towards Medical Technology of the Future”. We hope that our meeting in Warsaw will result in many presentations of realistic ideas, which will give not only a hope but will lead to efficient substitution or regeneration of the lost functions of the organism.

Ruth Schwartlander receives grant

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In vitro comparison test concerning the MELS CellModule and the AMC-BAL are currently performed in cooperation with the Academisch Medisch Centrum (AMC) in Amsterdam...

Florian Vondran receives grant

The International Program Committee of the 24th International Congress of The
Transplantation Society is pleased to invite the submission of scientific abstracts.

Please use this
link to submit your abstract!