BMBF prize for medical technology awarded

This book is the proceedings of the Falk Symposium No. 145 on ‘Artificial Liver Support’, held on 27--28 January 2005 in Ulm, Germany, and provides an overview of the possibilities and limitations of the existing procedures and devices available for artificial liver support. The book is written for clinicians, researchers, graduate students, and academics.
For more than 25 years clinicians and scientists have been trying to improve the treatment of acute hepatic failure. Several devices were developed and hemodialysis procedures were refined. The treatment of fulminant hepatic failure and end-stage liver cirrhosis by liver transplantation became a standard procedure. However, for the successful management of critical situations before and after liver surgery, artificial liver support is still needed. The results achieved with albumin dialysis (MARS System), the Prometheus System, and dialysis and hemofiltration or plasma exchange as well as modular extracorporeal liver support (MELS) and the Amsterdam bioartificial liver (AMC BAL) are discussed in detail regarding their effects in different clinical situations.
In the second half of the book, the remaining problems and expectations for the future of clinical hepatocyte transplantation and stem cell therapy are elucidated.
Leading experts in the fields of artificial devices, bioartificial devices, hepatocyte transplantation and stem cells present the latest data on these topics. Their experience and their data are summarized in this volume, thus providing an exceptional overview of the problems and future perspectives in the field of artificial liver support.
Artificial Liver Support Series: Falk Symposium, Vol. 145 Henne-Bruns, D.; Buttenschön, K.; Fuchs, M.; Lohse, A. (Eds.) Springer-Verlag 2005 (ISBN: 1-4020-3239-0)

BMBF awarded new grant

The SlideReactor - A Simple Hollow Fiber Based Bioreactor Suitable for Light Microscopy (Igor M. Sauer, Ruth Schwartlander, Jochen Schmid, Ekaterina Efimova, Florian W.R. Vondran, Daniel Kehr, Gesine Pless, Antonino Spinelli, Börries Brandenburg, Eberhardt Hildt, and Peter Neuhaus) was published in the latest issue of Artificial Organs, Volume 29 Issue 3 Page 264 ff.  - March 2005: Most bioartificial liver support systems are based on hollow fiber capillaries within modified dialysis cartridges or more sophisticated bioreactor constructions. Due to their design microscopic follow-up of reorganization and growth of tissue between the hollow fibers is not possible. The SlideReactor is a simple hollow fiber based bioreactor construction suitable for light microscopy and time-lapse video observation. The SlideReactor offers a cell compartment separated from a medium inflow and outflow compartment. Cell compartment access ports enable easy filling of the cell compartment with cell suspension, as well as fixation of the tissue. For more complex procedures or full access to all the cells, the bioreactor can be opened easily by cutting the silicone seal with a scalpel. Due to its simple design and the utilization of standard materials, it could serve as a suitable, cost-efficient tool to evaluate the behavior of cells cultured between hollow fiber capillaries. The paper describes the production process: similar to open source projects in software engineering, we would like to propose the concept as an open platform to anyone interested in hollow fiber based cell culture.

BMBF Forschungsprämie

The traditional One Day on the Liver will be part of the XXXVI Annual Meeting of the European Society for Artificial Organs ESAO 2009 at the Université de Technologie de Compiègne in France. ODOL 2009 will take place September, 3rd focussing on "Cells, Hybrids, and Machines".
The following keynote lectures will be given:
Clinical Results of Liver Cell Therapy in Children with Urea Cycle Defect by Dr. Dr. W. Rüdinger, Weinheim, Germany,
Xenotransplantation. Where are we in 2009 ?
by Dr. A. Billiau, Leuven, Belgium,
Problems and Opportunities: Perspectives of Bioartificial Liver Support
by Dr. R. Hoekstra, Amsterdam, Netherlands,
New perspectives of artificial liver support
by Prof. Dr. D. Falkenhagen, Krems, Austria.

We expect to present you all lectures as video streams after the meeting.