Our novel concept of metabolic reprogramming envisions reconstitution of endogenous repair in severely steatotic liver grafts during extracorporeal machine perfusion in the period between explantation and implantation.

A new approach to overcome organ scarcity by in vitro generation of tissue and organ structures is decellularisation and recellularisation of tissues or whole organs. This concept is based on the idea of composing biologic scaffolds by removing cellular and antigen-presenting components from tissues or organs.

With the growing disparity between the number of suitable donor organs and patients waiting for transplantation, efforts have been made to optimize the allocation of organs, to find alternatives to cadaveric liver transplantation and to develop extracorporeal methods of support.