Modern academic and clinical surgery increasingly demands a fundamental understanding of the individual’s tumor biology. State-of-the art oncologic research paves the way for in-depth characterization and investigation of molecular signatures responsible for carcinoma development. The focus of the Molecular Carcinogenesis Lab is to investigate the genomic determinants responsible for pancreato-biliary tumor initiation and progression. We use modern tools like Next-Generation Sequencing, single-cell transcriptomics, genome engineering and three-dimensional tissue culture to address basic- and translational research questions around pancreato-biliary carcinogenesis.
Info Funded by BIH – Berlin Institute of Health and the Charité, Clinician Scientist Programm and the Berliner Krebsgesellschaft (BKG), FEFF202108 and Else Kröner Fresenius Stiftung (EKFS, 2022_EKEA.74)
Methodologies and projects
Three-dimensional tissue cultures
Gene editing of pancreato-biliary driver genes in-vitro
Short- and long-read sequencing techniques
Investigating the tumor microenvironment
Single cell transcriptomics of pancreato-biliary neoplasia