Comment on "Endotoxin, not DNA, determines the host response and tissue regeneration behavior of acellular biologic scaffolds"
E. Keshi, I.M. Sauer, K. Hillebrandt
Selection is based on our experimental projects and involvement of our laboratories.
Regarding publications of the Dept. of Surgery, CCM|CVK, (in particular clinical projects) we would like to refer to Medline.
Comment on "Endotoxin, not DNA, determines the host response and tissue regeneration behavior of acellular biologic scaffolds"
E. Keshi, I.M. Sauer, K. Hillebrandt
Thrombogenicity assessment of perfusable tissue engineered constructs: a systematic review
L.M. Haderer, Y. Zhou, P. Tang, A. Daneshgar, B. Globke, F. Krenzien, A. Reutzel-Selke, M. Weinhart, J. Pratschke, I.M. Sauer, K.H. Hillebrandt, E. Keshi
Quality assessment by bile composition in normothermic machine perfusion of rat livers
V. Muth, F. Stobl, J. Michelotto, J.A. Kirwan, J. Marchand, N.N. Roschke, S. Moosburner, J. Pratschke, I.M. Sauer, N. Raschzok, J.M.G.V. Gassner
A new bicornuate model of rat uterus transplantation
D. Polenz, I.M. Sauer, F. Martin, A. Reutzel-Selke, M.I. Ashraf, A. Schirmeier, S. Lippert, K. Führer, J. Pratschke, S.G. Tullius, S. Moosburner.
Distinctive protein expression in elderly livers in a Sprague-Dawley rat model of normothermic ex vivo liver machine perfusion
M. Zimmer, K.H. Hillebrandt, N.M. Roschke, S. Lippert, O. Klein, G. Nebrich, J.M.G.V. Gassner, F. Strobl, J. Pratschke, F. Krenzien, I.M. Sauer, N. Raschzok, S. Moosburner
Multinational Analysis of Marginal Liver Grafts Based on the Eurotransplant Extended Donor Criteria
S. Moosburner, M.S. Patel, B.K. Wang, J. Prasadh, R. Öllinger, G. Lurje, I.M. Sauer, P.A. Vagefi, J. Pratschke, N. Raschzok
Comment on "Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multi-Center, Real-World Risk-Matched Analysis"
K.A. Walter, M.S. Patel, I.M. Sauer, J. Pratschke, N. Raschzok, S. Moosburner
Chemistry matters: A side-by-side comparison of two chemically distinct methacryloylated dECM bioresins for vat photopolymerization
A. Almalla, L. Elomaa, N. Fribiczer, T. Landes, P. Tang, Z. Mahfouz, B. Koksch, K.H. Hillebrandt, I.M. Sauer, D. Heinemann, S. Seiffert, M. Weinhart
Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants
M.I. Ashraf, J. Mengwasser, A. Reutzel-Selke, D. Polenz, K. Führer, S. Lippert, P. Tang, E. Michaelis, R. Catar, J. Pratschke, Ch. Witzel, I.M. Sauer, S.G. Tullius, B. Kern
Optimizing environmental enrichment for Sprague Dawley rats: Exemplary insights into the liver proteome
N.N. Roschke, K.H. Hillebrandt, D. Polenz, O. Klein, J.M.G.V. Gassner, J. Pratschke, F. Krenzien, I.M. Sauer, N. Raschzok, S. Moosburner.
Proteomic analysis of decellularized mice liver and kidney extracellular matrices
A.M. Diedrich, A. Daneshgar, P. Tang, O. Klein, A. Mohr, O.A. Onwuegbuchulam, S. von Rueden, K. Menck, A. Bleckmann, M.A. Juratli, F. Becker, I.M. Sauer, K.H. Hillebrandt, A. Pascher, B. Struecker
miRNA as potential biomarkers after liver transplantation: A systematic review
P.F. Koch, K. Ludwig, F. Krenzien, K.H. Hillebrandt, W. Schöning, J. Pratschke, N. Raschzok, I.M. Sauer, S. Moosburner
Improved outcomes after hypothermic oxygenated machine perfusion in liver transplantation-Long-term follow-up of a multicenter randomized controlled trial.
Z. Czigany, D. Uluk, S. Pavicevic, I. Lurje, J. Froněk, Th. Keller, P. Strnad, D. Jiang, T. Gevers, D. Koliogiannis, M. Guba, R.H. Tolba, F.A. Meister, U.P. Neumann, M. Kocik, M. Kysela, I.M. Sauer, N. Raschzok, W. Schöning, I. Popescu, F. Tacke, J. Pratschke, G. Lurje
Towards a 3D-printed perfusable islet embedding structure: technical notes and preliminary results
E. Keshi, P. Tang, T. Lam, S. Moosburner, L.M. Haderer, A. Reutzel-Selke, L. Kloke, J. Pratschke, I.M. Sauer, K.H. Hillebrandt
Papain-Based Solubilization of Decellularized Extracellular Matrix for the Preparation of Bioactive, Thermosensitive Pregels
A. Almalla, L. Elomaa, L. Bechtella, A. Daneshgar, P. Yavvari, Z. Mahfouz, P. Tang, B. Koksch, I. Sauer, K. Pagel, K.H. Hillebrandt, M. Weinhart
Rise of tissue- and species-specific 3D bioprinting based on decellularized extracellular matrix-derived bioinks and bioresins
L. Elomaa, A. Almalla, E. Keshi, K.H. Hillebrandt, I.M. Sauer, M. Weinhart
Moderate LMWH anticoagulation improves success rate of hind limb allotransplantation in mice
B. Kern, M.-I. Ashraf, A. Reutzel-Selke, J. Mengwasser, D. Polenz, E. Michaelis, J. Pratschke, S.G. Tullius, Ch. Witzel, I.M. Sauer
Development and systematic evaluation of decellularization protocols in different application models for diaphragmatic tissue engineering
M.N. Andreas, A.K. Boehm, P. Tang, S. Moosburner, O. Klein, A. Daneshgar, J.M.G.V. Gaßner, N. Raschzok, D. Wulsten, J.-C. Rückert, S. Spuler, J. Pratschke, I.M. Sauer, K.H. Hillebrandt
Advancing perfusion models: Dual-vessel ex vivo rat liver perfusion based on a clinical setup
F. Strobl, J. Michelotto, V. Muth, S. Moosburner, K. Knaub, M. Zimmer, M. Patel, J. Pratschke, I.M. Sauer, N. Raschzok, J.M.G.V. Gassner
How many liver transplantations could be recovered after implementation of donation after cardiac death in Germany?
S. Moosburner, I.M. Sauer, B. Weiß, J. Pratschke, N. Raschzok
Validation of risk scores for allograft failure after liver transplantation in Germany: a retrospective cohort analysis
S. Moosburner, L. Wiering, N. Roschke, A. Winter, Axel; M. Demir, J.M.G.V. Gaßner, M. Zimmer, P. Ritschl, B. Globke, G. Lurje, F. Tacke, W. Schöning, J. Pratschke, R. Öllinger, I.M. Sauer, N. Raschzok
Augmenting Image-Guided Procedures through In Situ Visualization of 3D Ultrasound via a Head-Mounted Display
F. von Haxthausen, Ch. Rüger, M.M. Sieren, R. Kloeckner, F. Ernst
Effect of pre-operative chemotherapy on the isolation outcome of primary human hepatocytes
M. Rissel, J. Pohl, S. Moosburner, J. Gaßner, R. Horner, K. Hillebrandt, D. Modest, J. Pratschke, I.M. Sauer, N. Raschzok
Ex Vivo Liver Machine Perfusion: Comprehensive Review of Common Animal Models
V. Muth, J.M.G.V. Gassner, S. Moosburner, G. Lurje, J. Michelotto, F. Strobl, K. Knaub, C. Engelmann, F. Tacke, M. Selzner, J. Pratschke, I.M. Sauer, N. Raschzok N
Tissue engineering for the diaphragm and its various therapeutic possibilities – A Systematic Review
A.K. Boehm, K.H. Hillebrandt, T. Dziodzio, F. Krenzien, J. Neudecker, S. Spuler, J. Pratschke, I.M. Sauer, M.N. Andreas
Smartphone Apps to Stratify the Risk of Early Allograft Failure Are Just the Beginning for Next-Generation Outcome Prediction in Transplantation Medicine
S. Moosburner, J.M.G.V. Gassner, J. Pratschke, I.M. Sauer, N. Raschzok
Immune Regulatory 1 Cells: A Novel and Potent Subset of Human T Regulatory Cells
N. Krause, J. Mengwasser, E. Phithak, F. Beato, M. Appis, E.L. Milford, J. Pratschke J, I. Sauer, A. Kuehl, A. Vogel, M. Goodyear, L. Hammerich, F. Tacke, J.F. Haas, T. Müller, N. Utku N
Donor-Specific Antibodies Against Donor Human Leukocyte Antigen are Associated with Graft Inflammation but Not with Fibrosis Long-Term After Liver Transplantation: An Analysis of Protocol Biopsies
S. Gül-Klein, H. Hegermann, R. Röhle, M. Schmelzle, F. Tacke, W. Schöning, R. Öllinger, T. Dziodzio, P. Maier, J.M. Plewe, D. Horst, I.M. Sauer, J. Pratschke, N. Lachmann, D. Eurich
Sensing Acute Cellular Rejection in Liver Transplant Patients Using Liver-Derived Extracellular Particles: A Prospective, Observational Study
K. Kamali, M. Schmelzle, C. Kamali, P. Brunnbauer, K. Splith, A. Leder, N. Berndt, K.H. Hillebrandt, N. Raschzok, L. Feldbrügge, M. Felsenstein, J. Gaßner, P. Ritschl, G. Lurje, W. Schöning, C. Benzing, J. Pratschke, F. Krenzien
Ex vivo machine perfusion: current applications and future directions in liver transplantation
J. Michelotto, J.M.G.V. Gassner, S. Moosburner, V. Muth, M.S. Patel, M. Selzner, J. Pratschke, I.M. Sauer, N. Raschzok
Extended liver resection in mice: state of the art and pitfalls – a systematic review
C. Kamali, K. Kamali, P. Brunnbauer, K. Splith, J. Pratschke, M. Schmelzle, F. Krenzien
Engineering an endothelialized, endocrine Neo-Pancreas: Evaluation of islet functionality in an ex vivo model
H. Everwien, E. Keshi, K.H. Hillebrandt, B. Ludwig, M. Weinhart, P. Tang , A.S. Beierle, H. Napierala, J.M. Gassner, N. Seiffert, S. Moosburner, D. Geisel, A. Reutzel-Selke, B. Strücker, J. Pratschke, N. Haep, I.M. Sauer
The Human Liver Matrisome – Proteomic Analysis of Native and Fibrotic Human Liver Extracellular Matrices for Organ Engineering Approaches
A. Daneshgar, O. Klein, G. Nebrich, M. Weinhart, P. Tang, A. Arnold, I. Ullah, J. Pohl, S. Moosburner, N. Raschzok, B. Strücker, M. Bahra, J. Pratschke, I.M. Sauer, K.H. Hillebrandt
Early Allograft Dysfunction Increases Hospital Associated Costs After Liver Transplantation-A Propensity Score-Matched Analysis
S. Moosburner, I.M. Sauer, F. Förster, T. Winklmann, J.M.G.V. Gassner, P.V. Ritschl, R. Öllinger, J. Pratschke, N. Raschzok
Declined Liver Grafts - Analysis of the German Donor Population from 2010 to 2018
S. Moosburner, N. Raschzok, C. Schleicher, D. Bösebeck, J.M.G.V. Gaßner, P.V. Ritschl, A. Rahmel, I.M. Sauer, J. Pratschke
Dual versus single vessel normothermic ex vivo perfusion of rat liver grafts using metamizole for vasodilatation
F. Claussen, J.M.G.V. Gassner, S. Moosburner, D. Wyrwal, M. Nösser, P. Tang, L. Wegener, J. Pohl, A. Reutzel-Selke, R. Arsenic, J. Pratschke, I.M. Sauer, N. Raschzok
Development of GelMA/PCL and dECM/PCL resins for 3D printing of acellular in vitro tissue scaffolds by stereolithography
L. Elomaa, E. Keshi, I.M. Sauer, M. Weinhart
Increased Cell-Free DNA Plasma Concentration Following Liver Transplantation Is Linked to Portal Hepatitis and Inferior Survival
F. Krenzien, S. Katou, A. Papa, B. Sinn, C. Benzing, L. Feldbrügge, C. Kamali, P. Brunnbauer, K. Splith, R.R. Lorenz, P. Ritschl, L. Wiering, R. Öllinger, W. Schöning, J. Pratschke, M. Schmelzle
The Effects of MELD-Based Liver Allocation on Patient Survival and Waiting List Mortality in a Country with a Low Donation Rate
P.V. Ritschl, L. Wiering, T. Dziodzio, M. Jara, J. Kruppa, U. Schoeneberg, N. Raschzok, F. Butz, B. Globke, P. Seika, M. Maurer, M. Biebl, W. Schöning, M. Schmelzle, I.M. Sauer, F. Tacke, R. Öllinger, J. Pratschke
Magnetic resonance elastography quantification of the solid-to-fluid transition of liver tissue due to decellularization
H. Everwien, A. Ariza de Schellenberger, N. Haep, H. Tzschätzsch, J. Pratschke, I.M. Sauer, J. Braun, K.H. Hillebrandt, I. Sack
Hospitalization before liver transplantation predicts post-transplant patient survival - a propensity-score matched analysis
L. Wiering, R. Öllinger, J. Kruppa, U. Schoeneberg, T. Dziodzio, M. Jara, M. Biebl, R. Dargie, N. Raschzok, W. Schöning, D. Eurich, M. Schmelzle, I.M. Sauer, J. Pratschke, P.V. Ritschl
Development of a rat liver machine perfusion system for normothermic and subnormothermic conditions
M. Nösser, J.M.G.V. Gassner, S. Moosburner, D. Wyrwal, F. Claussen, K.H. Hillebrandt, R. Horner, P. Tang, A. Reutzel-Selke, D. Polenz, R. Arsenic, J. Pratschke, I.M. Sauer, N. Raschzok
Hepatocyte Transplantation to the Liver via the Splenic Artery in a Juvenile Large Animal Model
J. Siefert, K.H. Hillebrandt, S. Moosburner, P. Podrabsky, D. Geisel, T. Denecke, J.K. Unger, B. Sawitzki, S. Gül-Klein, S. Lippert, P. Tang, A. Reutzel-Selke, M.H. Morgul, A.W. Reske, S. Kafert-Kasting, W. Rüdinger, J. Oetvoes, J. Pratschke, I.M. Sauer, N. Raschzok
Macrosteatosis is a huge problem in liver transplantation – however, not the only one we face
S. Moosburner, I.M. Sauer, J.M.G.V, Gassner, C. Schleicher, D. Bösebeck, A. Rahmel, J. Pratschke, N. Raschzok
Strategies based on organ decellularization and recellularization
K.H. Hillebrandt, H. Everwien, N. Haep, E. Keshi, J. Pratschke, I.M. Sauer
Diagnostic Biomarkers to Diagnose Acute Allograft Rejection After Liver Transplantation: Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies
F. Krenzien, E. Keshi, K. Splith, S. Griesel, K. Kamali, I.M. Sauer, L. Feldbrügge, J. Pratschke, A. Leder, M. Schmelzle
Impact of Percoll purification on isolation of primary human hepatocytes
R. Horner, J.G.M.V. Gassner, M. Kluge, P. Tang, S. Lippert, K.H. Hillebrandt, S. Moosburner, A. Reutzel-Selke, J. Pratschke, I.M. Sauer, N. Raschzok
First Healthy Baby After Deceased Donor Uterus Transplantation: Birth to a New Era?
M.M. Maurer, I.M. Sauer, J. Pratschke, S.G. Tullius
Human Stem Cells Promote Liver Regeneration After Partial Hepatectomy in BALB/C Nude Mice
S. Wabitsch, C. Benzing, F. Krenzien, K. Splith, P.K. Haber, A. Arnold, M. Nösser, C. Kamali, F. Hermann, C. Günther, D. Hirsch, I.M. Sauer, J. Pratschke, M. Schmelzle
Mixed and Augmented Reality – Why Surgeons Should Care
M. Queisner, J. Pratschke, I.M. Sauer
Composite tissue allotransplantation: opportunities and challenges
J. Iske, Y. Nian, R. Maenosono, M. Maurer, I.M. Sauer, S.G. Tullius
High donor age for liver transplantation : Tackling organ scarcity in Germany
S. Moosburner, P.V. Ritschl, L. Wiering, J.M.G.V. Gassner, R. Öllinger , J. Pratschke, i.M. Sauer, N. Raschzok
Liver Assist Systems for Bridging to Transplantation: Devices and Concepts
N. Raschzok, K.H. Hillebrandt, I.M. Sauer
Improvement of normothermic ex vivo machine perfusion of rat liver grafts by dialysis and Kupffer Cell inhibition with glycine
J.M.G.V. Gassner, M. Nösser, S. Moosburner, R. Horner, P. Tang, L. Wegener, D. Wyrwal, F. Claussen, R. Arsenic, J. Pratschke, I.M. Sauer, N. Raschzok
Real world usability analysis of two augmented reality headsets in visceral surgery.
S. Moosburner, C. Remde, P. Tang, M. Queisner, N. Haep, J. Pratschke, I.M. Sauer
Prevalence of Steatosis Hepatis in the Eurotransplant Region: Impact on Graft Acceptance Rates
S. Moosburner, J.M.G.V. Gassner, M. Nösser, J. Pohl, D. Wyrwal, F. Claussen, P.V. Ritschl, D. Dragun, J. Pratschke, I.M. Sauer, N. Raschzok
Liver Transplantation and Liver Resection for Cirrhotic Patients with Hepatocellular Carcinoma: Comparison of Long-Term Survivals
F. Krenzien, M. Schmelzle, B. Struecker, N. Raschzok, C. Benzing, M. Jara, M. Bahra, R. Öllinger, I.M. Sauer, A. Pascher, J. Pratschke, A. Andreou
Living-Donor Liver Transplant: An Analysis of Postoperative Outcome and Health-Related Quality of Life in Liver Donors
C. Benzing, M. Schmelzle, R. Oellinger, K. Gruettner, A.K. Muehlisch, N. Raschzok, I.M. Sauer, M. Bahra, J. Pratschke, S. Guel-Klein
Plasma expansion is key for sustained liver function and viability during normothermic and subnormothermic ex vivo machine perfusion in a rat model
J.M.G.V. Gassner, M. Nösser, R. Horner, K.H. Hillebrandt, S. Moosburner, L. Wegener, P. Demko, R. Arsenic, B. Struecker, J. Pratschke, I.M. Sauer, N. Raschzok
Mixed Reality in visceral surgery – development of a suitable workflow and evaluation of intraoperative use-cases
I.M. Sauer, M. Queisner, P. Tang, S. Moosburner, O. Hoepfner, R. Horner, R. Lohmann, J. Pratschke
Computed tomography-based survey of the vascular anatomy of the juvenile Göttingen minipig
J. Siefert, K.H. Hillebrandt, M. Kluge, D. Geisel, P. Podrabsky, T. Denecke, M. Nösser, J. Gassner, A. Reutzel-Selke, B. Strücker, M.H. Morgul, S. Guel-Klein, J.K. Unger, A. Reske, J. Pratschke, I.M. Sauer, N. Raschzok
Isolation, characterization and cold storage of cells isolated from diseased explanted livers
E. Belaschk, S. Rohn, R. Mukiibi, A. Reutzel-Selke, P. Tang, B. Sawitzki, J. Pratschke, I.M. Sauer, M.T. Mogl
Engineering an endocrine Neo-Pancreas by repopulation of a decellularized rat pancreas with islets of Langerhans
H. Napierala, K. Hillebrandt, N. Haep, P. Tang, M. Tintemann, J. Gassner, M. Noesser, H. Everwien, N. Seiffert, M. Kluge, E. Teegen, D. Polenz, S. Lippert, D. Geisel, A. Reutzel-Selke, N. Raschzok, A. Andreou, J. Pratschke, I.M. Sauer, B. Struecker
The value of microparticles in detecting acute rejection episodes after liver transplantation
M.H. Morgul, K. Splith, C. Leonhardt, N. Raschzok, A. Reutzel-Selke, R.B. Schmuck, A. Andreou, C. Atanasov, C. Benzing, F. Krenzien, H.M. Hau, P. Felgendreff, S. Klunk, J. Pratschke, I.M. Sauer, M. Schmelzle
Bile: miRNA pattern and protein based biomarkers may predict acute cellular rejection after liver transplantation
R.B. Schmuck, A. Reutzel-Selke, N. Raschzok, M.H. Morgul, B. Struecker, S. Lippert, C. de Carvalho Fischer, M. Schmelzle, S. Boas-Knoop, M. Bahra, A. Pascher, J. Pratschke, I.M. Sauer
Improved rat liver decellularization by arterial perfusion under oscillating pressure conditions
B. Struecker, A. Butter, K. Hillebrandt, D. Polenz , A. Reutzel-Selke, P. Tang, S. Lippert, A. Leder, S. Rohn, D. Geisel, T. Denecke, K. Aliyev, K. Jöhrens, N. Raschzok, P. Neuhaus, J. Pratschke, I.M. Sauer
Evolution of graft morphology and function after recellularization of decellularized rat livers
A. Butter, K. Aliyev, K.-H. Hillebrandt, N. Raschzok, M. Kluge, N. Seiffert, P. Tang, H. Napierala, M.I. Ashraf, A. Reutzel-Selke, A. Andreou, J. Pratschke, I.M. Sauer, B. Struecker
Hepatocyte isolation after laparoscopic liver resection
R. Horner*, M. Kluge*, R.M. Major, A. Reutzel-Selke, J. Gassner, M. Nösser, B. Strücker, M.H. Morgül, J. Pratschke, I.M. Sauer, N. Raschzok
Allogeneic liver transplantation and subsequent syngeneic hepatocyte transplantation in a rat model – proof of concept for in vivo tissue engineering
S. Rohn, J. Schroeder, H. Riedel, D. Polenz, K. Stanko, A. Reutzel-Selke, P. Tang, L. Brusendorf, N. Raschzok, P. Neuhaus, J. Pratschke, B. Sawitzki, I.M. Sauer, M.T. Mogl
microRNA signatures in peripheral blood fail to detect acute cellular rejection after liver transplantation
N. Raschzok, A. Reutzel-Selke, R. Schmuck, L. Tannus, M. Morgul, C. Dietel, A. Leder, B. Struecker, S. Lippert, H. Sallmon, M. Schmelzle, M. Bartels, S. Jonas, J. Pratschke, I.M. Sauer
Single Pass Albumin Dialysis (SPAD) – A dose finding study to define optimal albumin concentration and dialysate flow
R.B. Schmuck, G.-H. Nawrot, P. Fikatas, A. Reutzel-Selke, J. Pratschke, I.M. Sauer
Human hepatocyte isolation: Does portal vein embolization affect the outcome?
M. Kluge, A. Reutzel-Selke, H. Napierala, K.H. Hillebrandt, R.D. Major, B. Struecker, A. Leder, J. Siefert, P. Tang, S. Lippert, D. Seehofer, J. Pratschke, I.M. Sauer, N. Raschzok
Implantation of a tissue engineered Neo Bile Duct in domestic pigs
B. Struecker, K. Hillebrandt, N. Raschzok, K. Jöhrens, A. Butter, P. Tang, A. Andreou, H. Napierala, D. Polenz, A. Reutzel-Selke, T. Denecke, J. Pratschke, I.M Sauer
The impact of directly acting antivirals on the enzymatic liver function of liver transplant recipients with recurrent hepatitis C
N. Raschzok, E. Schott, A. Reutzel-Selke, I. Damrah, S. Gül-Klein, B. Strücker, I.M. Sauer, J. Pratschke, D. Eurich, M. Stockmann
Acute graft dysfunction 17 years after liver transplant: A challenging clinical and histologic manifestation of hepatitis E
K.H. Hillebrandt, R. Arsenic, J. Hofmann, D. Eurich, S. Gül, B. Strücker, I.M. Sauer, J. Pratschke, M. Stockmann, N. Raschzok
microRNAs in liver tissue engineering – new promises for failing organs
N. Raschzok, H. Sallmon, J. Pratschke, I.M. Sauer
Tumor DNA-index and α-fetoprotein level define outcome following liver transplantation for advanced hepatocellular carcinoma.
Andreou A, Bahra M, Guel S, Struecker B, Sauer IM, Klein F, Pascher A, Pratschke J, Seehofer D.
Procedure for Decellularization of Rat Livers in an Oscillating-pressure Perfusion Device
K. Hillebrandt, D. Polenz, A. Butter, P. Tang, A. Reutzel-Selke, A. Andreou, H. Napierala, N. Raschzok, J. Pratschke, I.M. Sauer, B. Struecker
CD44 and CXCL9 serum protein levels predict the risk of clinically significant allograft rejection after liver transplantation
N. Raschzok, A. Reutzel-Selke, R.B. Schmuck, M.H. Morgul, U. Gauger,K.A. Prabowo, L.-M. Tannus, A. Leder, B. Struecker, S. Boas-Knoop, M. Bartels, S. Jonas, Ch. Lojewski, G. Puhl, D. Seehofer, M. Bahra, A. Pascher, J. Pratschke, I.M. Sauer
Tissue Engineered Grafts – 160 Years After R. Virchow's Omnis Cellula e Cellula
I.M. Sauer
Micron-sized iron oxide-containing particles for microRNA-targeted manipulation and MRI-based tracking of transplanted cells
A. Leder*, N. Raschzok*, C. Schmidt, D. Arabacioglu, A. Butter, S. Kolano, L.S. de Sousa Lisboa, W. Werner, D. Polenz, A. Reutzel-Selke, J. Pratschke, I.M. Sauer
Liver support strategies: cutting-edge technologies
B. Struecker, N. Raschzok, I.M. Sauer
Porcine liver decellularization under oscillating pressure conditions – A technical refinement to improve the homogeneity of the decellularization process
B. Struecker, K. Hillebrandt, R. Voitl, A. Butter, R.B. Schmuck, A. Reutzel-Selke, D. Geisel, K. Joehrens, P.A. Pickerodt, N. Raschzok, G. Puhl, P. Neuhaus, J. Pratschke, I.M. Sauer
Independent Effects of Sham Laparotomy and Anesthesia on Hepatic microRNA Expression in Rats
W. Werner, H. Sallmon, A. Leder, S. Lippert, A. Reutzel-Selke, M.H. Morgül, S. Jonas, S. Dame, P. Neuhaus, J. Iacomini, S.G. Tullius, I.M. Sauer, N. Raschzok
Functionalizable silica-based micron-sized iron oxide particles for cellular Magnetic Resonance Imaging
N. Raschzok, C.M. Langer, Ch. Schmidt, K.H. Lerche, N. Billecke, K. Nehls, N.B. Schlüter, A. Leder, S. Rohn, M.T. Mogl, L. Lüdemann, L. Stelter, U.K. Teichgräber, P. Neuhaus, I.M. Sauer
APACHE III score is superior to King's College Hospital criteria, MELD score and APACHE II score to predict outcomes after liver transplantation for acute liver failure
P. Fikatas, J.E. Lee, I.M. Sauer, S.C. Schmidt, D. Seehofer, G. Puhl, O. Guckelberger
Survival without biliary complications after liver transplant for primary sclerosing cholangitis
M.T. Mogl, K. Albert, A. Pascher, I. Sauer, G. Puhl, S. Gül, C. Schönemann, P. Neuhaus, O. Guckelberger
Noninvasive monitoring of liver cell transplantation
N. Raschzok, H.M. Morgül, L. Stelter, I.M. Sauer
Feasibility of fast dynamic MRI for non-invasive monitoring during ectopic liver cell transplantation to the spleen in a porcine model
N. Raschzok, J. Pinkernelle, N. Billecke, K. Nehls, M. Powerski, I.M. Sauer, U. Teichgraber
Improvement of the cold storage of isolated human hepatocytes
G. Pless, I.M. Sauer, U. Rauen
Labelling of primary human hepatocytes with micron-sized iron oxide particles in suspension culture suitable for large-scale preparation
N.N. Kammer, N. Billecke, M.H. Morgul, M.K. Adonopoulou, M. Mogl, M.D. Huang, S. Florek, K.R.L. Schmitt, N. Raschzok, I.M. Sauer
CARS microscopy for the visualization of micrometer-sized iron oxide MRI contrast agents in living cells
G. Rago, C.M. Langer, C. Brackman, J.P. Day, K.F. Domke, N. Raschzok, C. Schmidt, I.M. Sauer, A. Enejder, M.T. Mogl, M. Bonn
The APACHE III score as preoperative indicator of patient outcome in liver transplantation after fulminant hepatic failure
P. Fikatas, F. Ulrich, J.E. Lee, I.M. Sauer, S. Chopra, S.C. Schmidt, A. Pascher, J. Pratschke
In vitro evaluation of magnetic resonance imaging contrast agents for labeling human liver cells: implications for clinical translation
N. Raschzok, D.A. Muecke, M.K. Adonopoulou, N. Billecke, W. Werner, N.N. Kammer, A. Zielinski, P.A. Behringer, F. Ringel, M.D. Huang, P. Neuhaus, U. Teichgräber, I.M. Sauer
Continuous veno-venous single-pass albumin hemodiafiltration in children with acute liver failure
H. Ringe, V. Varnholt, M. Zimmering, W. Luck, A. Gratopp, K. König, S. Reich, I.M. Sauer, G. Gaedicke, U. Querfeld
Monitoring of liver cell transplantation in a preclinical swine model using Magnetic Resonance Imaging
N. Raschzok, U. Teichgräber, N. Billecke, A. Zielinski, K. Steinz, N.N. Kammer, M.H. Morgul, S. Schmeisser, M.K. Adonopoulou, L. Morawietz, B. Hiebl, R. Schwartlander, W. Rüdinger, B. Hamm, P. Neuhaus, I.M. Sauer
Aging of the liver graft and functional quality in the absence of recurrent disease: a 10 year histological follow-up
M. Schmeding, I.M. Sauer, K. Hartwig, T. Theruvath, J. Pratschke, R. Neuhaus, P. Neuhaus, U.P. Neumann
Quantification of Cell Labelling with Micron-Sized Iron Oxide Particles Using Continuum Source Atomic Absorption Spectrometry
N. Raschzok, N. Billecke, N.N. Kammer, M.H. Morgul, M.K. Adonopoulou, I.M. Sauer, S. Florek, H. Becker-Ross, M.-D. Huang
Sonographically guided placement of intravenous catheters in minipigs
J. Pinkernelle, N. Raschzok, U. Teichgräber
Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes
T. Deurholt, N.P. van Til, A.A. Chhatta, L. ten Bloemendaal, R. Schwartlander, C. Payne, J.N. Plevris, I.M. Sauer, R.A. Chamuleau, R.P. Elferink, J. Seppen, R. Hoekstra
Aspergillus spondylodiscitis after multivisceral transplantation
U.A. Gerlach, S. Kohler, I.M. Sauer, D. Joerres, F. Kandziora, P. Neuhaus, J. Pratschke, A. Pascher
Tacrolimus and methylprednisolone prevent hypothermia induced endothelial dysfunction
A. Diestel, N. Billecke, J. Roessler, B. Schmitt, S. Troeller, R. Schwartlander, F. Berger, I.M. Sauer*, K.R.L. Schmitt*
Journal of Heart and Lung Transplantation, 2009, 28: 718-724 (IF: 3.514)
Successful treatment of invasive sphenoidal, pulmonary and intracerebral aspergillosis after multivisceral transplantation
S. Kohler, U. Gerlach, O. Guckelberger, I.M. Sauer, D. Jörres, P. Neuhaus, J. Pratschke, A. Pascher
Imaging of Primary Human Hepatocytes Using Micron-Sized Iron Oxide Particles and Clinical Magnetic Resonance Tomography
N. Raschzok*, M.H. Morgul*, J. Pinkernelle, F.W.R. Vondran, N. Billecke, N.N. Kammer, G. Pless, M.K. Adonopoulou, C. Leist, L. Stelter, U. Teichgraber, R. Schwartlander, I.M. Sauer
Tracking of primary human hepatocytes with clinical MRI – initial results with Tat-peptide modified superparamagnetic iron oxide particles
M.H. Morgul*, N.Raschzok*, R. Schwartlander, F.W.R. Vondran, R. Michel, L. Stelter, J. Pinkernelle, A. Jordan, U. Teichgraber, I.M. Sauer
Isolation of primary human hepatocytes after partial hepatectomy – Criteria for identification of the most promising liver specimen
F.W.R.Vondran, E. Katenz, R. Schwartlander, M.H. Morgul, N. Raschzok, X.B.Gong, X.D. Cheng, D. Kehr, I.M. Sauer
Graft versus host disease after liver transplantation - a single center experience and review of literature
S. Kohler, A. Pascher, G. Junge, I.M. Sauer, M. Nagy, C. Schönemann, M. Koch, U. Neumann, J. Pratschke, P. Neuhaus
Artificial and Bioartificial Liver Support
G. Pless
Organogenesis 2007, 3: 20-24
Cryopreservation of primary human hepatocytes – the benefit of trehalose as an additional cryoprotective agent
E. Katenz, F.W.R. Vondran, R. Schwartlander, G. Pless, X. Gong, X. Cheng, P. Neuhaus, I. M. Sauer
Influence of basiliximab induction therapy on long term outcome after liver transplantation, a prospectively randomised trial
M. Schmeding, I.M. Sauer, A. Kiessling, J. Pratschke, R. Neuhaus, P. Neuhaus, U.P. Neumann
First in vitro comparison of two bioartificial liver support systems: MELS CellModule and AMC-BAL
P.P.C. Poyck, G. Pless, R. Hoekstra, S. Roth, A.C.W.A. van Wijk, R. Schwartlander, T.M. van Gulik, I.M. Sauer, R.A.F.M. Chamuleau
Evaluation of primary human liver cells in bioreactor cultures for extracorporeal liver support on the basis of urea production
G. Pless, I. Steffen, K. Zeilinger, I.M. Sauer, E. Katenz, D.C. Kehr, S. Roth, T. Mieder, R. Schwartlander, Ch. Müller, B. Wegner, M. S. Hout, P. Neuhaus, J.C. Gerlach
Cell-free artificial liver support
I.M. Sauer, U. Baurmeister
Therapeutic Apheresis and Dialysis 2006, 10: 105-107 (IF: 1.177)
Novel system for efficient gene transfer into primary human hepatocytes via cell permeable HBV virus-like particle
B. Brandenburg, L. Stockl, C. Gutzeit, M. Roos, J. Lupberger, R. Schwartlander, H. Gelderblom, I.M. Sauer, P.H. Hofschneider, E. Hildt
The SlideReactor - a simple hollow fiber based bioreactor suitable for light microscopy
I.M. Sauer, R. Schwartlander, J. Schmid, E. Efimova, F.W.R. Vondran, D. Kehr, G. Pless, A. Spinelli, B. Brandenburg, E. Hildt, and P. Neuhaus
Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth
Schumacher G, Oidtmann M, Rueggeberg A, Jacob D, Jonas S, Langrehr JM, Neuhaus R, Bahra M, Neuhaus P.
Clinical results of intestinal and multivisceral transplantation at the Charité, Berlin
A. Pascher, J. Klupp, R.J. Schulz, S. Kohler, G. Junge, I.M. Sauer, W. Veltzke-Schlieker, A. Adler, O. Guckelberger, N.C. Nussler, A. Dignass, J.M. Langrehr, P. Neuhaus
In vitro evaluation of the transportability of viable primary human liver cells originating from discarded donor organs in bioreactors
I.M. Sauer, R. Schwartlander, O. van der Jagt, I. Steffen, E. Efimova, G. Pless, D.C. Kehr, D. Kardassis, J.H. Fruhauf, J.C. Gerlach, P. Neuhaus
Artificial Organs 2005, 29: 141-151 (IF: 1.946)
The European artificial organ scene: present status
R. Vanholder, J. de Cañizo, I.M. Sauer, B Stegmayr
Bioartificial liver: current status
G. Pless, I.M. Sauer
In vitro comparison of the Molecular Adsorbent Recirculation System (MARS) and Single Pass Albumin Dialysis (SPAD)
I.M. Sauer, M. Goetz, I. Steffen, G. Walter, D.C. Kehr, R. Schwartlander, Y.J. Hwang, A. Pascher, J.C. Gerlach, P. Neuhaus
Effects of human hepatocyte growth factor on the proliferation of human hepatocytes and hepatocellular carcinoma cell lines
E.A. Efimova, M. Glanemann, L. Liu, G. Schumacher, U. Settmacher, S. Jonas, J.M. Langrehr, P. Neuhaus, A.K.Nussler
Bilirubin-adsorption in 23 critically ill patients with liver failure
R. Senf, R. Klingel, S. Kurz, S. Tullius, I.M. Sauer, U. Frei, R. Schindler
The use of primary human liver cells originating from discarded grafts in a bioreactor for liver support therapy and the prospects of culturing adult liver stem cells in bioreactors – a morphological study
J.C. Gerlach, K. Mutig, I.M. Sauer, P. Schrade, E. Efimova, T. Mieder, G. Nauman, A. Grünwald, G. Pleß, A. Mas, S. Bachmann, P. Neuhaus, K. Zeilinger
Extracorporeal Liver Support based on Primary Human Liver Cells and Albumin Dialysis – Treatment of a Patient with Primary Graft Non-Function
I.M. Sauer, K. Zeilinger, G. Pless, D. Kardassis, T. Theruvath, A. Pascher, M. Goetz, P. Neuhaus, J. C. Gerlach
Porcine endogenous retroviruses (PERVs): No infection in patients treated with a bioreactor based on porcine liver cells
M. Irgang, I.M. Sauer, A. Karlas, K. Zeilinger, J.C. Gerlach, R. Kurth, P. Neuhaus, J. Denner
Clinical extracorporeal hybrid liver support – phase I study with primary porcine liver cells
I.M. Sauer, D. Kardassis, K. Zeillinger, A. Pascher, A. Gruenwald, G. Pless, M. Irgang, M. Kraemer, G. Puhl, J. Frank, A.R. Müller, Th. Steinmüller, J. Denner, P. Neuhaus, J. C. Gerlach
Successful infliximab treatment of steroid and OKT3 refractory acute cellular rejection in two patients after intestinal transplantation
A. Pascher, C. Radke, A. Dignass, R.J. Schulz, W. Veltzke-Schlieker, A. Adler, I.M. Sauer, K. Platz, J. Klupp, H.D. Volk, P. Neuhaus, A.R. Mueller
Late Graft Loss After Intestinal Transplantation in an Adult Patient as a Result of Necrotizing Enterocolitis
A. Pascher, C. Radke, A. Dignass, R. Schulz, I.M. Sauer, K. Platz, J. Klupp, P. Neuhaus, A. Mueller
Recovery of Preservation Injured Primary Human Hepatocytes and Nonparenchymal Cells to Tissue-Like Structures in Large-Scale Bioreactors for Liver Support: An Initial Transmission Electron Microscopy Study
J.C. Gerlach, K. Zeilinger, A. Grebe, G. Puhl, G. Pless, I.M. Sauer, A. Grunwald, N. Schnoy, C. Muller, P. Neuhaus
Einsatz biologischer Leberunterstützungssysteme bei der Therapie des Leberversagens – Modular Extracorporeal Liver Support (MELS)
T.P. Theruvath, I.M. Sauer, D. Kardassis, N. Obermayer, A. Pascher, M. Goetz, A.R. Mueller, Th. Steinmueller, P. Neuhaus, J.C. Gerlach
Verdauungskrankheiten 2003, 21: 32-40
Concept for modular extracorporeal liver support for the treatment of acute hepatic failure
I.M. Sauer, P. Neuhaus, J.C. Gerlach
Extracorporeal liver support: Porcine or human cell based systems?
J.C. Gerlach, K. Zeilinger, I.M. Sauer, T. Mieder, G. Naumann, A. Grünwald, G. Pless, G. Holland, A. Mas, J. Vienken, P. Neuhaus
Sirolimus inhibits growth of human hepatoma cells in contrast to tacrolimus which promotes cell growth
Schumacher G, Oidtmann M, Rosewicz S, Langrehr J, Jonas S, Mueller AR, Rueggeberg A, Neuhaus R, Bahra M, Jacob D, Gerlach H, Neuhaus P.
Primary human liver cells as source for modular extracorporeal liver support – a preliminary report
I.M. Sauer, K. Zeilinger, N. Obermayer, G. Pless, A. Pascher, T. Mieder, S. Roth, M. Goetz, D. Kardassis, A. Mas, P. Neuhaus, J.C. Gerlach
International Journal of Artificial Organs 2002, 25: 1001-1005 (IF: 1.192)
Analysis of allogeneic versus xenogeneic auxiliary organ perfusion in liver failure reveals superior efficacy of human livers
A. Pascher, I.M. Sauer, P. Neuhaus
International Journal of Artificial Organs 2002, 25: 1006-1012 (IF: 1.192)
Three-dimensional Co-culture of Primary Human Liver Cells in Bioreactors for In Vitro Drug Studies: Effects of the Initial Cell Quality on the Long-term Maintenance of Hepatocyte-specific Functions.
K. Zeilinger K, I.M. Sauer, G. Pless, C. Strobel, J. Rudzitis, A. Wang, A.K. Nussler, A. Grebe, L. Mao, S.H. Auth, J. Unger, P. Neuhaus, J.C. Gerlach
Modified surgical technique in clinical small bowel transplantation: donor and recipient management.
A. Mueller, A. Pascher, K. Platz, N. Nussler, R. Schulz,D. Horch,T. Melitz,I. M. Sauer, R. Eisele,U. Settmacher,A. Dignass,E. Lopez-Henninen,H. Weidemann,P. Neuhaus
Transplantation Proceedings 2002; 34: 2265 (IF: 0.478)
Living-Donation Liver Transplantation for Hepatocellular Carcinoma: Time to Drop the Limitations?
Th. Steinmüller, A. Pascher, I.M. Sauer, T. Theruvath, A.R. Müller, U.Settmacher, P. Neuhaus
Transplantation Proceedings 2002; 34: 2263-2264 (IF: 0.478)
A method to assess biochemical activity of liver cells during clinical application of extracorporeal liver support
A. Mundt, G. Puhl, A. Müller, I. Sauer, C. Müller, R. Richard, C. Fotopoulou, R. Doll, G. Gäblein, W. Höhn, R. Hofbauer, P. Neuhaus, J. Gerlach
Modular Extracorporeal Liver Support (MELS)
I.M. Sauer, J.C. Gerlach
Extracorporeal Liver Perfusion as Hepatic Assist in Acute Liver Failure - A Review of World Experience
A. Pascher, I.M. Sauer, C. Hammer, J.C. Gerlach, P. Neuhaus
[Right lobe living donor liver transplantation between adults]
T. Steinmuller, A. Pascher, I.M. Sauer, T. Theruvath, A.R. Muller, U. Settmacher , P. Neuhaus
Use of inferior mesenteric vein for venous anastomosis in clinical small bowel transplantation.
K.P. Platz, A. Pascher, R.J. Schulz, N.C. Nussler, I.M. Sauer, U. Settmacher, R. Eisele, A. Dignass, E. Lopez-Henninen, P. Neuhaus, A.R. Mueller
Transplantation Proceedings 2002, 34: 906-907 (IF: 0.478)
Monitoring of immunosuppression after clinical small bowel transplantation.
A. Pascher, I.M. Sauer, R.J. Schulz, K. Platz, T. Theruvath, A. Dignass, C. Radke, P. Neuhaus, A.R. Mueller
Transplantation Proceedings 2002, 34: 931-933 (IF: 0.478)
Experimental evaluation of a cell module for hybrid liver support
J.C. Gerlach, M. Botsch, D. Kardassis, P. Lemmens, M. Schoen, J. Janke, G. Puhl, J. Unger, M. Kraemer, B. Busse, B. Boehmer, R. Belal, M. Ingenlath, M. Kosan, B. Kosan, J. Sueltmann, A. Patzold, S. Tietze, R. Roissant, C. Mueller, E. Moench, I.M. Sauer, P. Neuhaus
Development of a hybrid liver support system
I.M. Sauer, N. Obermayer, D. Kardassis, T. Theruvath, J.C. Gerlach
Modular Extracorporeal Liver Support (MELS) bei Leberversagen
D. Kardassis, T.P. Theruvath, I.M. Sauer, J.C. Gerlach, P. Neuhaus
Journal für Anästhesie und Intensivbehandlung 2001, 3: 97-99
Split liver and living donation liver transplantation: the Berlin experience.
I.M. Sauer, A. Pascher, Th. Steinmueller, U. Settmacher, A.R. Müller, W.O. Bechstein, P. Neuhaus
Transplantation Proceedings 2001; 33: 1459-1460 (IF: 0.568)
Multiorgantransplantation
I.M. Sauer, A. Pascher, R. Pfitzmann, A.R. Mueller, P. Neuhaus
Chirurgische Praxis 2000, 57: 411-427
TAH Ovalis - Development and in vitro testing of a new electromechanical energy converter for a total artificial heart
I.M. Sauer, J. Frank, A.Spiegelberg, E.S. Bücherl
An unusual case of early pancreas graft loss.
I.M. Sauer, A. Kahl, A.R. Müller, P. Neuhaus, W.O. Bechstein
Proposal of a new electro-mechanical heart: TAH Serpentina
I.M. Sauer, J. Frank, E.S. Bücherl
Engineering an endocrine Neo-Pancreas. In: Decellularized Extracellular Matrix: Characterization, Fabrication and Applications (Editors: Tetsuji Yamaoka, Takashi Hoshiba)
E. Keshi, I.M. Sauer, K.H. Hillebrandt
Liver Assist Systems for Bridging to Transplantation: Devices and Concepts. In: Critical Care for Potential Liver Transplant Candidates (Editors: (D. Bezinover and F. Saner)
N. Raschzok, K.H. Hillebrandt, I.M. Sauer
Preclinical swine models for monitoring of hepatocyte transplantation by MRI Hepatocyte Transplantation – Methods and Protocols (Editors: Stock, Christ)
N. Raschzok, U. Teichgräber, J. Pratschke, I.M. Sauer
Springer Verlag, 2017 (ISBN: 978-1-4939-6506-9)
Extracorporeal Liver Support, Liver-Cell Transplantation, and Bioengineered Substitutes. In: Textbook of Organ Transplantation (Editors: Kirk, Knechtle, Larsen, Pearson, Webber)
I.M. Sauer, N. Raschzok, P. Neuhaus
Wiley-Blackwell, 2014 (ISBN: 978-1-118-87014-3)
Extracorporeal liver support. In: Management of acute kidney problems (Editors: Ronco, Kellum, Jörres)
I.M. Sauer
Springer Verlag, 2009 (ISBN: 978-3-540-69413-7)
Hybride Organe: Künstliche und zellbasierte Leberunterstützungssysteme. In: Chirurgische Forschung (Editors: Krukemeyer, Spiegel)
I.M. Sauer, P. Neuhaus
Georg Thieme Verlag, 2006: 366-378 (ISBN: 3-13-133661-7)
Modular Extracorporeal Liver Support. In: Artificial Liver Support (Editors: Henne-Bruns, Buttenschön, Fuchs, Lohse) Falk-Symposium, Vol. 145, 2005
I.M. Sauer
Springer Verlag, 2005: 53-60 (ISBN: 1-4020-3239-0)
Extrakorporale Leberunterstützungssysteme. In: Aktuelle Aspekte der Lebertransplantation (Editors: Neuhaus, Pfitzmann)
G. Puhl, I.M. Sauer
UniMed-Verlag, 2. Edition, 2005: 60-69 (ISBN 3-89599-774-9)
Liver Transplantation. In: Surgical treatment. Evidence-based and problem-oriented (Editor: Mannick)
I.M. Sauer, W.O. Bechstein, P. Neuhaus
Zuckschwerdt Verlag, München, Bern, Wien, New York: 298-305 (ISBN: 3-88603-714-2)
Bioartificial Organs III: Tissue Sourcing, Immunoisolation, and Clinical Trials (Editors: Hunkeler, Cherrington, Prokop, and Rajotte)
I.M. Sauer, N. Obermayer, D. Kardassis , T. Theruvath and J.C. Gerlach
Annals of the New York Academy of Sciences 2001, 944: 308-320 (ISBN: 1-57331-342-4)
Hepatozyten-Tissue Engineering und Bioreaktoren für hybride Leberunterstützungssysteme (Editor: Encke)
I.M. Sauer, J.C. Gerlach, P. Neuhaus
Deutsche Gesellschaft für Chirurgie – Kongressband 2000 : 764-769
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