022 TTS Mentee-Mentor-Award" /> 022 TTS Mentee-Mentor-Award"> 022 TTS Mentee-Mentor-Award"> 022 TTS Mentee-Mentor-Award"> 022 TTS Mentee-Mentor-Award"> 022 TTS Mentee-Mentor-Award"> 2022 TTS Mentee-Mentor-Award
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2022 TTS Mentee-Mentor-Award
In: Award
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Dr. Barbara Kern und Prof. Dr. Stefan G. Tullius received the 2022 Mentee-Mentor-Award of The Transplant Society during the 29th Conference in Buenos Aires.

In collaboration with National and International Societies, TTS acknowledges and recognizes the efforts of scientists who have advanced our understanding of transplantation science and fostered the development of young investigators.
The Mentee-Mentor Awards are designed to encourage dialogue and interactions between trainees and established investigators, and provide financial support for their joint participation in the Congress.

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Our manuscript "Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants" has been accepted for publication in Frontiers in Immunology, section Alloimmunity and Transplantation. Authors are Muhammad Imtiaz Ashraf, Joerg Mengwasser, Anja Reutzel-Selke, Dietrich Polenz, Kirsten Führer, Steffen Lippert, Peter Tang, Edward Michaelis, Rusan Catar, Johann Pratschke, Christian Witzel, Igor M. Sauer, Stefan G. Tullius, and Barbara Kern.

Acute cellular rejection remains a significant obstacle affecting successful outcomes of organ transplantation including vascularized composite tissue allografts (VCA). Donor antigen presenting cells (APC), particularly dendritic cells (DC), orchestrate early alloimmune responses by activating recipient effector T cells. Employing a targeted approach, we investigated the impact of donor-derived conventional DC (cDC) and APC on the immunogenicity of skin and skin-containing VCA grafts, using mouse models of skin and hind limb transplantation.
By post-transplantation day 6, skin grafts demonstrated severe rejections, characterized by predominance of recipient CD4 T cells. In contrast, hind limb grafts showed moderate rejection, primarily infiltrated by CD8 T cells. While donor depletion of cDC and APC reduced frequencies, maturation, and activation of DC in all analysed tissues of skin transplant recipients, reduction in DC activities was only observed in the spleen of hind limb recipients. Donor cDC and APC depletion did not impact all lymphocyte compartments but significantly affected CD8 T cells and activated CD4 T in lymph nodes of skin recipients. Moreover, both donor APC and cDC depletion attenuated the Th17 immune response, evident by significantly reduced Th17 (CD4+IL-17+) cells in the spleen of skin recipients and reduced levels of IL-17E and lymphotoxin-α in the serum samples of both skin and hind limb recipients. In conclusion, our findings underscore the highly immunogenic nature of skin component in VCA. The depletion of donor APC and cDC mitigates the immunogenicity of skin grafts while exerting minimal impact on VCA.

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