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Design Lab #13: Material Legacies
The exhibition »Design Lab #13: Material Legacies« at Kunstgewerbemuseum Berlin, opening on November 3rd, 2022, explores contingencies and ruptures between traditional crafts and the most recent developments at the crossroads of material research, design, engineering, and architecture. It brings together artifacts from the museum’s collection with work-in-progress installations by designers and researchers from the Cluster of Excellence »Matters of Activity. Image Space Material« in order to initiate a dialogue about the historical, contemporary, and future conditions under which materiality unfolds.

By engaging with a series of different materials and techniques the exhibition encompasses both the problematization of unsustainable pasts and presents as well as the imagination of speculative material futures. Taking materiality as a starting point, each of the exhibits will investigate its sociocultural, economic, and political context in order to disentangle the multiple interrelations that arise from and with materials. As such »Design Lab #13: Material Legacies« aims to challenge the passive understandings of materiality and associate with the widening discourse on relational knowledge practices in arts, design, humanities, and social science.

The exhibition will be running from 4 November 2022 to 26 February 2023. For the exhibition announcement on the website of the
Staatliche Museen zu Berlin – Preußischer Kulturbesitz.

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Exhibition Opening

3 November 2022, 6 pm

The opening event will include an introduction to the exhibition by Dr. Claudia Banz, Curator of Design at the Kunstgewerbemuseum Berlin, and Prof. Dr. Claudia Mareis, co-director of the Cluster of Excellence »Matters of Activity. Image Space Material«. Moreover, exhibition curators Michaela Büsse and Emile De Visscher will provide background on the exhibition, its goals, and how the curatorial process was undertaken.
The exhibition opening is part of the Berlin Science Week 2022.
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Our manuscript "Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants" has been accepted for publication in Frontiers in Immunology, section Alloimmunity and Transplantation. Authors are Muhammad Imtiaz Ashraf, Joerg Mengwasser, Anja Reutzel-Selke, Dietrich Polenz, Kirsten Führer, Steffen Lippert, Peter Tang, Edward Michaelis, Rusan Catar, Johann Pratschke, Christian Witzel, Igor M. Sauer, Stefan G. Tullius, and Barbara Kern.

Acute cellular rejection remains a significant obstacle affecting successful outcomes of organ transplantation including vascularized composite tissue allografts (VCA). Donor antigen presenting cells (APC), particularly dendritic cells (DC), orchestrate early alloimmune responses by activating recipient effector T cells. Employing a targeted approach, we investigated the impact of donor-derived conventional DC (cDC) and APC on the immunogenicity of skin and skin-containing VCA grafts, using mouse models of skin and hind limb transplantation.
By post-transplantation day 6, skin grafts demonstrated severe rejections, characterized by predominance of recipient CD4 T cells. In contrast, hind limb grafts showed moderate rejection, primarily infiltrated by CD8 T cells. While donor depletion of cDC and APC reduced frequencies, maturation, and activation of DC in all analysed tissues of skin transplant recipients, reduction in DC activities was only observed in the spleen of hind limb recipients. Donor cDC and APC depletion did not impact all lymphocyte compartments but significantly affected CD8 T cells and activated CD4 T in lymph nodes of skin recipients. Moreover, both donor APC and cDC depletion attenuated the Th17 immune response, evident by significantly reduced Th17 (CD4+IL-17+) cells in the spleen of skin recipients and reduced levels of IL-17E and lymphotoxin-α in the serum samples of both skin and hind limb recipients. In conclusion, our findings underscore the highly immunogenic nature of skin component in VCA. The depletion of donor APC and cDC mitigates the immunogenicity of skin grafts while exerting minimal impact on VCA.

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