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In: Meetings written by: Prof. Dr. Igor M. Sauer
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The 24th International Congress of The Transplantation Society to be held in Berlin, Germany from July 15th - 19th 2012 is designed for physicians, surgeons, scientists and organ procurement personnel, who are interested in clinical and research aspects of solid organ, cell and tissue transplantation. The program is developed to encourage the exchange of new scientific and clinical information, and support an interchange of opinions regarding care and management issues, as well as socioeconomic, ethical and regulatory issues relevant to transplantation.
In addition to the classical types of scientific sessions including plenary sessions, symposia, workshops and poster presentations, we will also offer new types of scientific sessions within the Forum Futurum.
The Forum Futurum is a forum integrated in the congress that will take place on three days. Each day is assigned to a topic and the forum is dedicated to cutting-edge science in our field. The topics are Regenerative Medicine, Imaging and Tailored Pharmacotherapy.
The Forum Futurum is designed to be a highly interactive communication space where companies can introduce their products and conversations about the latest research are stirred. In a futuristic environment the Forum Futurum contributes to an extraordinary TTS 2012 Exhibition experience and will provide exhibitors the opportunity to highlight new product information to physicians and health care professionals. Enhance the educational element of your company's noteworthy products and services with a presentation in the Forum Futurum. The Forum Futurum provides exhibitors with a unique and effective marketing opportunity to hold live promotional presentations or activities designed to raise awareness of featured services and products.
The Forum Futurum will make its debut in the TTS 2012 Exhibit Hall, featuring experts from companies and scientific groups providing state-of-the-art content-led information about new technologies, products and ideas. The Forum Futurum will be open July 16th – July 18th. Every day is dedicated to one emerging field in transplantation:
Monday, July 16th, 2012: One Day on Regenerative Medicine
Tuesday, July 17th, 2012: One Day on Imaging
Wednesday, July 18th, 2012: One Day on Tailored Pharmacotherapy
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Our manuscript "Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants" has been accepted for publication in Frontiers in Immunology, section Alloimmunity and Transplantation. Authors are Muhammad Imtiaz Ashraf, Joerg Mengwasser, Anja Reutzel-Selke, Dietrich Polenz, Kirsten Führer, Steffen Lippert, Peter Tang, Edward Michaelis, Rusan Catar, Johann Pratschke, Christian Witzel, Igor M. Sauer, Stefan G. Tullius, and Barbara Kern.

Acute cellular rejection remains a significant obstacle affecting successful outcomes of organ transplantation including vascularized composite tissue allografts (VCA). Donor antigen presenting cells (APC), particularly dendritic cells (DC), orchestrate early alloimmune responses by activating recipient effector T cells. Employing a targeted approach, we investigated the impact of donor-derived conventional DC (cDC) and APC on the immunogenicity of skin and skin-containing VCA grafts, using mouse models of skin and hind limb transplantation.
By post-transplantation day 6, skin grafts demonstrated severe rejections, characterized by predominance of recipient CD4 T cells. In contrast, hind limb grafts showed moderate rejection, primarily infiltrated by CD8 T cells. While donor depletion of cDC and APC reduced frequencies, maturation, and activation of DC in all analysed tissues of skin transplant recipients, reduction in DC activities was only observed in the spleen of hind limb recipients. Donor cDC and APC depletion did not impact all lymphocyte compartments but significantly affected CD8 T cells and activated CD4 T in lymph nodes of skin recipients. Moreover, both donor APC and cDC depletion attenuated the Th17 immune response, evident by significantly reduced Th17 (CD4+IL-17+) cells in the spleen of skin recipients and reduced levels of IL-17E and lymphotoxin-α in the serum samples of both skin and hind limb recipients. In conclusion, our findings underscore the highly immunogenic nature of skin component in VCA. The depletion of donor APC and cDC mitigates the immunogenicity of skin grafts while exerting minimal impact on VCA.

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