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TTS 2012 | Over 500 presentations online!
In: Meetings written by: Prof. Dr. Igor M. Sauer

The LOC would like to thank all participants for a tremendous 24th International Congress of The Transplantation Society in Berlin!
2268 abstracts were submitted and more than 4800 delegates from 94 countries attended the congress!
The Postgraduate Weekend offered 14 workshops with 45 speakers. Beside 29 Sunrise Symposia with 103 Speakers, 34 State of the Art Sessions with 138 speakers and five Plenary Sessions (16 speakers) we had 53 sessions with 465 oral presentations and 37 sessions with 287 mini oral presentations !
Furthermore, we would like to thank Astrid Enke, Lena Dochat and Stefanie Rensch (Interplan) and the technical experts at m-Events for their excellent work !
As Science and Medicine is nothing without vivid life we would like to thank Rotfront, Berlin Comedian Harmonists and the Capital Dance Orchestra for their memorable performances!

All the great photos by Jan Pauls.
The organ sculptures were made by Jan Pareike.

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Our manuscript "Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants" has been accepted for publication in Frontiers in Immunology, section Alloimmunity and Transplantation. Authors are Muhammad Imtiaz Ashraf, Joerg Mengwasser, Anja Reutzel-Selke, Dietrich Polenz, Kirsten Führer, Steffen Lippert, Peter Tang, Edward Michaelis, Rusan Catar, Johann Pratschke, Christian Witzel, Igor M. Sauer, Stefan G. Tullius, and Barbara Kern.

Acute cellular rejection remains a significant obstacle affecting successful outcomes of organ transplantation including vascularized composite tissue allografts (VCA). Donor antigen presenting cells (APC), particularly dendritic cells (DC), orchestrate early alloimmune responses by activating recipient effector T cells. Employing a targeted approach, we investigated the impact of donor-derived conventional DC (cDC) and APC on the immunogenicity of skin and skin-containing VCA grafts, using mouse models of skin and hind limb transplantation.
By post-transplantation day 6, skin grafts demonstrated severe rejections, characterized by predominance of recipient CD4 T cells. In contrast, hind limb grafts showed moderate rejection, primarily infiltrated by CD8 T cells. While donor depletion of cDC and APC reduced frequencies, maturation, and activation of DC in all analysed tissues of skin transplant recipients, reduction in DC activities was only observed in the spleen of hind limb recipients. Donor cDC and APC depletion did not impact all lymphocyte compartments but significantly affected CD8 T cells and activated CD4 T in lymph nodes of skin recipients. Moreover, both donor APC and cDC depletion attenuated the Th17 immune response, evident by significantly reduced Th17 (CD4+IL-17+) cells in the spleen of skin recipients and reduced levels of IL-17E and lymphotoxin-α in the serum samples of both skin and hind limb recipients. In conclusion, our findings underscore the highly immunogenic nature of skin component in VCA. The depletion of donor APC and cDC mitigates the immunogenicity of skin grafts while exerting minimal impact on VCA.

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